摘要
目的探讨采用 3.0TMR 研究脊髓扩散张量纤维束示踪(DTT)技术的可行性及其临床应用价值。方法研究对象分病例组(40例脊髓压迫症患者)和对照组(20名正常志愿者)。病例组包括30例颈椎间盘突出症及颈椎病、9例椎管内肿瘤和1例陈旧性颈椎外伤。采用单次激励自旋回波平面回波成像(EPI)行脊髓扩散张量成像(DTI)。利用纤维束追踪软件重组脊髓纤维束。结果在 DTF 彩色编码图上,正常脊髓纤维束为头尾向的一束,显示了头尾侧的各向异性。设置2个感兴趣区(ROI)法显示了纤维束交叉及主要的脊髓纤维束,如皮质脊髓束或脊髓丘脑束。其中10名正常志愿者进行了包括中脑的 DTI,8名两侧的纤维束显示不对称,2名两侧对称。病例组所有患者均显示脊髓纤维束不同程度的受压或破坏。所有颈椎病患者及3例髓外硬膜下神经鞘瘤患者显示纤维束受压但无破坏,1例髓内室管膜瘤显示纤维束明显受压伴有少许破坏。结论 DTT 技术能直观显示脊髓纤维束及其异常改变,对脊髓压迫症能提供有价值的信息,有助于受压脊髓白质束的精确定位及损伤程度的判断。
Objective To study the feasibility and clinical values of diffusion tensor tractography （DTT） in the spinal cord at 3.0 T MR. Methods Forty patients with spinal cord compression including cervical cord herniation and cervical spendylosis （30 cases）, tumors in spinal canal （9 cases） and old injury in cervical vertebrae （ 1 cases） and 20 healthy volunteers participated in this study. Single-shot spinecho echo-planar diffusion tensor sequence for tractography of the spinal cord was performed. The fibers of spinal cord were visualized by using fiber tracking software. Results On the DTT maps, the normal spinal cord was depicted as a fiber tract showing color-encoded cephalocandally, which indicated anisotropy in the cephalocandal direction. By setting two ROI, the main spinal cord fiber tracts, such as corticospinal or spinothalamic tract, were visualized. The tracts from two sides of the brain did not completely cross. It was asymmetric in the number of tracts on the two sides in most normal subjects （8/10）. The tracts of all patients with cord compression were seen oppressed or damaged in different degrees. The DTT in patients with cervical spondylosis and extramedullary-intradural neurolemmoma demonstrated that tracts were oppressed but not damaged. The DTT in one ependymoma showed that tract was markedly compressed and slightly damaged. Conclusion DTT is a promising tool for demonstrating the spinal cord tracts and abnormalities, can provide useful information for the localization of compression and evaluation of the impairment extent on the white matter tracts of the spinal cord.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2007年第2期148-152,共5页
Chinese Journal of Radiology
关键词
磁共振成像
脊髓压迫症
扩散
Magnetic resonance imaging
Spinal cord compression
Diffusion
