摘要
目的 探讨云南彝族2型糖尿病与HLA-DRB1等位基因多态性的关联。方法 采用聚合酶链反应．序列特异性引物技术，对云南楚雄地区彝族2型糖尿病患者79例和同地区47名彝族正常对照进行HLA-DRB1等位基因分型，做2型糖尿病与HLA-DRB1等位基因多态性关联分析。结果 云南彝族2型糖尿病组与正常对照组相比，DR7、DR11等位基因频率均高于正常对照组，差异有统计学意义（P=0．009，RR=8．329；P=0．029，RR=7．734）。结论 DR7、DR11等位基因可能是云南彝族2型糖尿病的易感基因。
Objective To investigate the association between the polymorphism of HLA-DRB1 alleles and type 2 diabetes mellitus in Yi nationality of Yunnan. Methods Polymerase chain reaction-sequence specific primers （ PCR- SSP） genotyping method was conducted in 79 patients with type 2 diabetes mellitus and 47 ethnically matched controls in Yi Nationality Autonomous Prefecture, Chuxiong. Results HLA-DR7 and DRll allele frenquencies in type 2 diabetic mellitus patients were significantly higher than those in non-diabetic control subjects respectively（ P = 0.009, RR = 8.329; P = 0.029,RR = 7.734）. Conclusion DR7 and DR11 alleles are probably susceptible genes of type 2 diabetes mellitus in Yunnan Yi nationality.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2007年第1期101-103,共3页
Chinese Journal of Medical Genetics
