摘要
目的比较加替沙星片与左氧氟沙星片治疗急性细菌性感染的疗效。方法应用m eta分析对有关加替沙星和左氧氟沙星治疗急性细菌性感染的临床疗效及细菌清除率进行定量综合分析,共入选10篇文献,可进行临床疗效评价病例992例,可进行细菌清除率比较病例1072例。结果同质性检验:细菌清除率比较,χ2=7.82,P=0.45;临床有效率比较,χ2=4.19,P=0.84;临床痊愈率比较,χ2=4.59,P=0.71;合并效应量的估计:细菌清除率比较,OR合并=0.98(0.63-1.53,Z=0.09,P=0.93);临床有效率比较,OR合并=1.29(0.80-2.10,Z=1.04,P=0.30);临床痊愈率比较,OR合并=1.21(0.89-1.63,Z=1.22,P=0.22)。结论国产加替沙星片与左氧氟沙星在治疗急性细菌性感染疾病的疗效相等。
Objective To compare the efficacies between gatifloxacin tablets and levofoxacin tablets in the treatment of acute bacterial infections. Methods The results of 10 random controlled trials in treating acute bacterial infections were analyzed by meta-analysis method. There were 992 cases analyzed to evaluate clinical efficacy and 1072 cases for bacterial clearance rate. Results The cited studies were homogeneous： in bacterial clearance rate analysis, with x^2=7.82 and P=0. 45; in clinical efficacy rates analysis, with x^2=4. 19 and P=0. 84 and in clinical cure rates analysis, with x^2=4.59 and P=0.71. Combined test showed, in bacterial clearance rate analysis, the combined OR=0.98 （0. 63-1.53, Z=0.09, P=0. 93）; in clinical efficacy rate analysis, there was 1.29 （0.80-2.10, Z=1.04, P=0. 30）, and in clinical cure rate analysis, there was 1.21 （0. 89- 1.63, Z = 1.22, P = 0.22）. Conclusions The efficacies of domestic gatifloxacin tablets and levofoxacin tablets were equally effective in the treatment of acute bacterial respiratory and urinary tract infection.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2007年第2期113-116,127,共5页
Chinese Journal of Antibiotics
