期刊文献+

血管内皮生长因子与肾疾病的研究 被引量:3

Vascular Endothelial Growth Factor and Nephropathy
下载PDF
导出
摘要 血管内皮生长因子(VEGF)是调节血管发生的基本生长因子,参与多种肾脏疾病的发病机制。通过干预VEGF可以达到缓解肾脏疾病,改善肾功能的目的。本文对VEGF在肾疾病发生和发展中的作用进行综述。 Vascular endothelial growth factor is an essential growth factor in regulating angiogenesis, which is associated with the pathogeneaia of some nephropathy. Interfering in VEGF can achieve the better rehal function by relieving its pathological proceeding. This article reviews VEGF about its effect in the genesis and development of renal diseases.
作者 王俏 杜勤
出处 《医学综述》 2007年第3期186-188,共3页 Medical Recapitulate
关键词 肾疾病 血管内皮生长因子 血管生成 Kidney disease Vascular endothelial growth factor Angiogenesi
  • 相关文献

参考文献19

  • 1Hideyasu O,Hitoshi T,Atsushi O,et al.Selective induction of neuropiln-1 by vascular endothelial growth factor[J].Proc Natl Acad Sci USA,2002,99 (1):383-388.
  • 2Wang L,Kwak JH,Kim SI,et al.Transforming growth factor-β1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase3-p38α and p38δ mitogen-activated protein kinase-dependent pathway in murine mesangial cells[J].J Biol Chem,2004,279(32):33213-33219.
  • 3Pupilli C,Lasagni L,Romagnani P,et al.Angiotensin Ⅱ stimulates the synthesis and secretion of vascular permeability factor/vascular endothelial growth factor in human mesangial cells[J].J Am Soc Nephrol,1999,10(2):245-255.
  • 4Gruden G,Araf S,Zonca S,et al.IGF-1 induces vascular endothelial growth factor in human mesangial cell via a Src-dependent mechanism[J].Kidney Int,2003,63(4):1249-1255.
  • 5Kang DH,Hughes J,Mazzali M,et al.Impaired angiogenesis in the remnant kidney model (Ⅰ):Potential role of vascular endothelial growth factor and thrombospondin-1[J].J Am Soc Nephrol,2001,12(7):1434-1447.
  • 6Awad BE,Kreft B,Wolber EM,et al.Hypoxia and interleukin-1βstimulate VEGF production in human proximal tubular cells[J].Kidney Int,2000,58(1):43-50.
  • 7Kim BS,Chen J,Weinstein T,et al.VEGF expession in hypoxia and hyperglycemia:reciprocal effect on branching angiogenesis in epithelialendothelial co-cultures[J].J Am Soc Nephrol,2002,13 (8):2027-2036.
  • 8Honkanen E,Teppo AM,Gronhagen-Riska C.Decreased urinary excretion of VEGF in idiopathic membranous glomerulonephritis[J].Kidney Int,2000,57 (6):2343 -2349.
  • 9Shulman K,Rosen S,Tognazzi K,et al.Expression of vascular permeability factor is altered in many glomerular diseases[J].J Am Soc Nephrol,1996,7 (5):661-666.
  • 10Thomas S,Vanuystel J,Gruden G,et al.VEGF receptors in human mesangium in vitro and in glomerular disease[J].J Am Soc Nephrol,2000,11(7):1236-1243.

同被引文献58

引证文献3

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部