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急性淋巴细胞性白血病患者血清IL-12、IFN-γ及LDH测定的临床意义 被引量:11

The clinical significance of the detection of serum IL-12,IFN-γ and LDH in patients with acute lymphocyte leukemia
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摘要 目的探讨急性淋巴细胞性白血病(ALL)患者血清白细胞介素12(IL-12)、γ干扰素(IFN-γ)及乳酸脱氢酶(LDH)测定的临床意义。方法采用酶联免疫吸附(ELISA)法测定36例ALL患者不同阶段IL-12、IFN-γ水平,全自动生化分析仪酶法测定LDH水平,并与正常对照组比较。结果ALL初诊组血清IL-12、IFN-γ明显低于正常对照组(P<0.01,<0.05),LDH明显高于正常对照组(P<0.01);IL-12与IFN-γ呈显著正相关(P<0.01)。完全缓解组血清IL-12和IFN-γ明显升高,与对照组无统计学差异;LDH较治疗前明显下降但仍高于正常对照组(P<0.01)。结论IFN-γ、IL-12和LDH变化可能与白血病细胞的生长及机体抗肿瘤免疫功能受损有关。 [Objective] To investigate the clinical significance of detecting the levels of serum IL-12,IFN-γ and LDH in patients with acute lymphocyte leukemia(ALL). [Methods] Serum levels of IL-12 and IFN-γ in different stage of 36 ALL patients were detected by ELISA method,concentration of LDH was assayed by auto biochemistry analyzer. They were contrasted to those of control group. [Results] The contents of IL-12 and IFN-γ in all patients with initial treatment were significantly lower than control group(P〈0. 01),while the content of LDH was significantly higher(P〈0.01) ; IL-12 had positive relation with IFN-γ(P〈0.01). The levels of serum IL-12 and IFN-γ in the patients of complete remission increased but there was no statistic difference compared with control group ; The level of LDH was significantly decreased than before, but it was still higher than control group. [-Conclusion] The change of serum IL-12,IFN-γ and LDH may be related to the growth of leukemia cells and the injury of human immune status of anti-tumor function.
出处 《山东医药》 CAS 北大核心 2007年第4期5-6,共2页 Shandong Medical Journal
关键词 白血病 淋巴细胞 急性 干扰素Ⅱ型 白细胞介素12 乳酸脱氢酶 leukemia, lymphocytic, acute interferon type Ⅱ ;interleukin- 12 ;lactate dehydrogenase
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  • 1Gollob JA,Murphy EA,Mahajan S,et al.Altered IL-12 responsiveness in Th1 and Th2 cells is associated with the differential of STAT5 and STATl[J].Blood.1998,91(4)t1341-1354.
  • 2Yamazaki K,Yano T,Kameyama T,et al.Clinical significance of serum Th1/Th2 cytokines in patients with pulmonary adenocarcinoma[J].Surgery,2002.131(1):236-241.
  • 3Ode N,Nikkei A,Hayashi R,et al.Utility of measuring serum parathyroid hormone-related protein concentration in leukemia patients with hypocaleaemia for assessing disease status[J].EuroJ Endocrinol.1998,139:323-329.
  • 4蒋红,刘志刚.小儿急性白血病患者血清IFN-γ和sFas测定及相关性研究[J].镇江医学院学报,2000,10(4):664-665. 被引量:2

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