摘要
目的探讨乌司他丁对食管癌手术所致肺炎性反应的影响。方法选择40例限期行食管癌根治术患者,随机分为对照组(n=20)和乌司他丁组(n=20)。乌司他丁组按5000U/kg给予乌司他丁,对照组以等量生理盐水代替。于手术前(T1),术中恢复双肺通气后10min(T2)、24h(T3)、48h(T4)各监测时点抽取静脉血3ml,并于T1和T2时点收集支气管肺泡灌洗液3ml。用ELISA法测定血浆及支气管肺泡灌洗液中IL-6、IL-8的浓度。结果两组患者T2、T3、T4时点的血浆及T2时点的支气管肺泡灌洗液中IL-6及IL-8浓度均升高,与术前比较差异有显著性(P<0.01)。乌司他丁组IL-6、IL-8增高幅度较C组小,两组比较有统计学差异(P<0.05)。结论食管癌手术存在炎性反应,乌司他丁可抑制血浆及支气管肺泡灌洗液中IL-6及IL-8浓度。
Objective To examine the effect of ulinastatin （UTI） on the inflammatory responses induced by oesophagectomy. Methods Forty patients with esophageal cancer （without serious hypertension, heart disease, or respiratory fimction impairment, including 34 men and 6 women aged 46 to 70 years） scheduled for oesophagectomy via left thoracotomy were randomly divided into control group （n=20） and UTI group （n=20）. Anesthesia induction and perioperative management followed the same protocols in the two groups, and in UTI group, patients received 5000 U/kg UTI while those in the control group were given the same volume of saline. Before operation （T1）, 10 min after recovery of two-lung ventilation （T2）, and 24 h （T3） and 48 h （T4） after operation, the venous blood sample was taken from the internal jugular vein and the plasma was separated and stored at -70 ℃ for later analysis of IL-6 and IL-8 with enzyme-linked immtmosorbent assay （ELISA）. The bronchoalveoar lavage fluid （BAFL） was also collected at T1 and T2 for IL-6 and IL-8 detection. Results IL-6, IL-8 levels in the plasma and BALF collected at Te-T4 increased significantly as compared with those in samples collected at T1, and their peak concentration inplasma and BALF samples were similar. 1L-6 and IL-8 levels in the UTI group were significantly lower than those in the control group during the time points of T2-T4. Conclusion Inflammatory responses occur during and after oesophagectomy, which can be inhibited with UTI.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2007年第1期81-83,共3页
Journal of Southern Medical University
关键词
食管肿瘤/外科学
手术并发症
乌司他丁
炎性反应
esophageal neoplasms/surgery
postoperative complication
ulinastatin
inflammatory response
