摘要
目的:观察FOLFOX4方案治疗国人晚期胃癌的近期疗效和毒副反应。方法:28例晚期胃癌患者,先给予FOLFOX4方案,即:奥沙利铂(L-OHP)85mg/m2静脉点滴2h,d1;亚叶酸钙(CF)200mg/m2静脉点滴,2h,d1、d2;随后氟尿嘧啶(5-FU)400mg/m2静脉推注,d1、d2,5-FU600mg/m2微泵持续静脉滴注22h,d1、d2。2周重复。4个周期后以WHO评价标准评价疗效和毒性。结果:全组28例均可评价,其中完全缓解(CR)2例,部分缓解(PR)14例,稳定(SD)7例,进展(PD)5例,总有效率(CR+PR)57.1%。中位肿瘤进展时间(TTP)5.5个月,中位生存时间(MST)为9个月。毒副反应主要是骨髓抑制,白细胞降低发生率达82.1%,其次为胃肠道反应,恶心呕吐发生率78.6%,口腔粘膜炎为21.4%,腹泻35.7%,无Ⅲ/Ⅳ度胃肠道反应;周围神经毒性发生率为46.4%。结论:FOLFOX4方案治疗国人晚期胃癌的近期疗效较好,毒副反应可以耐受,值得进一步研究应用。
Objective：To evaluate the efficacy and adverse effects of oxaliplatin combined with 5-fiuorouracil （5-FU） and calcium folinate in the treatment of patients with advanced gastric cancer. Methods：Twenty eight patients with advanced gastric cancer received chemotherapy of regimen L-OHP 85mg,/m^2 2 hours d1 , CF 200mg/m^2 2 hours d1 , d2, followed by 5-FU 400mg/m^2 iv and 600mg/m^2 22 hours civ d1 , d2, two weeks as one cycle. Efficacy was evaluated after 4 cycles. Results：Two patients achieved complete response（CR） , 14 patients partial response（PR） , 7 patients stable disease（SD） , 5 patients progression disease（PD）. Overall response rate was 57. 1%. The major toxicity included nausea, vomiting, leucopenia and neurosensory. Conclusion：This study shows that the regimen of FOLFOX4 is effective and tolerable in advanced gastric cancer.
出处
《临床肿瘤学杂志》
CAS
2007年第2期123-124,共2页
Chinese Clinical Oncology
关键词
晚期胃癌
奥沙利铂
亚叶酸钙
氟尿嘧啶
化疗
Advanced Gastric Cancer
Oxaliplatin
Calcium folinate
5-Fluorouracil
Chemotherapy
