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上皮-间质转化信号转导在肾间质纤维化中机制的研究进展 被引量：10

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作者 赵宗江 李相辉
机构地区 北京中医药大学基础医学院
出处 《中国中西医结合肾病杂志》 2007年第2期113-115,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 教育部"长江学者和创新团队发展计划"资助项目(NoIRT0413) 国家自然科学基金重点资助项目(No30130220) 国家中医管理局中医药科研基金资助项目(No2000J-P-31)
关键词 肾小管上皮细胞 肾间质纤维化 信号转导 转化 丝状肌动蛋白 细胞表型 片状伪足 细胞-细胞
分类号 R692 [医药卫生—泌尿科学]
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参考文献21

  • 1Kalluril R,Neillson EG.Epithelial-mesenchymal transition and its implications for fibrosis.J Clin Invest,2003,112 (12):1776-1784.
  • 2Zavadil J,Bitzer M,Liang D,et al.Genetic programs of epithelial cell plasticity directed by transforming growth factor-b.Proc Natl Acad Sci USA,2001,98 (12):6686-6691.
  • 3Bhowmick NA,Zent R,Ghiassi M,et al.Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity.J Biol Chem,2001,276(50):46707-46713.
  • 4Okada H,Danoff TM,Kalluri R,et al.Early role of Fsp1 in epithelial-mesenchymal transformation.Am J Physiol,1997,273(4 Pt 2):563-574.
  • 5Morali OG,Delmas V,Moore R,et al.IGF-Ⅱ induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition.Oncogene,2001,20 (36):4942-4950.
  • 6Strutz F,Zeisberg M,Ziyadeh FN,et al.Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation.Kidney Int,2002,61(5):1714-1728.
  • 7Nightingale J,Patel S,Suzuki N,et al.Oncostatin M,a cytokine released by activated mononuclear cells,induces epithelial cellmyofibroblast transdifferentiation via Jak/Stat pathway activation.J Am Soc Nephrol,2004,15(1):21-32.
  • 8Bar-Sagi D,Hall A.Ras and Rho GTPases:a family reunion.Cell,2000,103 (2):227-238.
  • 9He X.A wnt-wnt situation.Dev Cell,2003,4(6):791-797.
  • 10Sadot E,Geiger B,Oren M,et al.Down-regulation of beta-catenin by activated p53.Mol Cell Biol,2001,21 (20):6768-6781.

二级参考文献37

  • 1Eddy AA. Molecular insights into the renal interstitial fibrosis. J Am Soc Nephrol, 1996,7:2495-2508.
  • 2Cees van Kooten, Mohamed R. Daha, Leendert A. van Es:Tubular epithelial cells:a critical cell type in the regulation of renal inflammatory processes. Exp Nephrol, 1999,7:429-437.
  • 3Goumenos DS, Tsamandas AC,Oldroy DS,et al. Transforming growth factor beta ( 1 ) and myofibroblasts: a potential pathway towards renal scarring in human glomerular disease. Nephren .2001.87:240-248.
  • 4Jinde K, Nikolic-Paterson DJ, Huang XR, et al. Tubular phenotypic change in progressive tubulointerstitial fibrosis in human glomerulonephritis. Am J Kidney Dis ,2001,38:761-769.
  • 5Sawashima K, Mizuno S, Mizuno-Horikawa Y, et al. Protein restriction ameliorates renal tubulointeratitial nephritis and reduces renal transforming growth factor-Beta expression in unilateral ureteral obstruction. Exp Nephre1,2002 ,10 :7-18.
  • 6Fan JM, Huang XR, Ng YY, et al. Interlukin-1 induce tubular epithelialmyoflbroblast transdifferentiation through a transforming growth factorbeta 1 dependent machanism in vitro. Am J Kidney Dis, 2001,37 : 820-830.
  • 7Sergio AM, Alejandra DM, Burgos ME, et al. Overexpression of chemokines, fibrogenic cytokines, and myofibroblasts in human membranous nephropathy. Kidney Int,2000,57 : 147-158.
  • 8Liapis H, Barent B, Sreinhardt GF. Extracellular matrix in fetal kidney after experimental obstruction. J Urol,2001,1664 : 1433-1438.
  • 9Gabbiani G, Ryan GB, Majno G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia, 1971,27 : 549 -550.
  • 10Tang WW, Van GY, Qi M. Myofibroblast and alpha 1 ( Ⅲ ) collagen expression in experimental tubulointerstitial nephritis. Kidney Int, 1997,51:926-931.

共引文献32

同被引文献137

引证文献10

二级引证文献73

中国中西医结合肾病杂志
2007年 第2期

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