摘要
目的探讨超声背向散射（IBS）技术评价乳腺癌术后患者表阿霉素心脏毒性的价值。方法133例乳腺癌患者分为3组：A组45例，给予表阿霉素总剂量180-240mg／m^2。B组48例，给予表阿霉素总剂量≥360mg／m^2。C组为对照组，40例，未给予化疗。取胸骨旁左室长轴切面，测量A、B两组化疗前后及C组左室后壁心内膜下及心外膜下、室间隔右室侧1／2及左室侧1／2心肌的平均背向散射积分（IBS）、随心动周期变化的背向散射积分幅度（CVIB），计算各层校正背向散射积分（IBS％）以及CVIB的跨壁梯度（TGCV）、CVIB的跨壁梯度指数（TGI）。结果A组与C组、A组化疗前之间常规超声参数（LVDd、LVDs、IVSTd、LVEF、FS、E／A）及CVIB、IBS％、TGCV、TGI无显著性差异（P〉0．05）。A组与B组间常规超声参数无显著性差异（P〉0．05），B组与C组及B两组化疗前之间常规超声参数（E／A除外）无显著性差异（P〉0．05）。B组参数E／A、CVIB、TGCV、TGI显著减低、IBS％显著升高，与A组、C组及B组化疗前之间有显著性差异（P〈0．05或P〈0．01）。结论超声背向散射技术可作为早期评价乳腺癌术后患者表阿霉素心脏毒性的手段之一。
Objective To investige the Eprirubincin-induced cardiotoxity in breast cancer patients by integrated backscatter. Methods One hundred and thirty-three breast cancer patients were divided into three groups： 45 patients in group A were given Epirubicin（Epi）of 180-240 mg/m^2 , 48 patients in group B were given Epirubicin of ≥360 mg/m^2 , and 40 patients after surging without chemotherapy in group C as the control group. The integrated backscatter （IBS）, cyclic variation of integrated backscatter（CVIB）were examined IBS%, then TGCV（transmural gradient of CVIB）, TGI（transmural gradient index of CVIB）were obtainedand. Results The conventional echographic parameters （such as LVDd, LVDs, IVSTd, LVEF, FS, E/A ） and CVIB, IBS%, TGCV, TGI were no significantce difference between group A and group C, so is it with A group before chemotherapy （P〉0. 05）. The conventional echographic parameters were no significant difference between groups A and B （P〉0. 05）. The conventional echographic parameters （E/A was not include） were no significant difference between group B and group C,so is it with group B before chemotherapy （P〉0.05）. The E/A and CVIB,TGCV, TGI were considerably lower, the IBS% was considerably higher in group B. They were significant difference between groups A and B, groups C and B, group A and group C,so is it with group B before chemotherapy （P〈0.01 or P〈0.05）. Conclusion IBS may be valuable to assess the Eprirubincin-induced cardiotoxity in breast cancer patients.
出处
《中国医学影像技术》
CSCD
北大核心
2007年第1期85-87,共3页
Chinese Journal of Medical Imaging Technology
