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环氧酶-2抑制剂的临床应用及研究进展评价 被引量:5

Clinical Application of Epoxidase-2 Inhibitors and Its Research Progress
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摘要 目的:介绍环氧酶-2抑制剂药物的临床应用进展,以期为临床医师、药师提供参考。方法:查阅国内、外近年来相关文献,对环氧酶-2抑制剂进行分析、评价。结果及结论:近年来对环氧酶-2抑制剂药物的研究比较广泛,使得COX的作用机制逐渐被了解,除了具有解热、镇痛、抗炎等作用外,在肿瘤治疗领域也有了新的进展。 OBJECTIVE: To introduce the progress in the clinical application of epoxidase - 2 inhibitors for references of clinician and pharmacists. METHODS: The related literatures both home and abroad were reviewed and an analysis and evaluation was conducted on epoxidase - 2 inhibitors. RESULTS & CONCLUSION : Recently, there is a widespread study on epoxidase - 2 inhibitors, which facilitates people' s understanding about the mechanism of COX. Epoxidase - 2 inhibitors exhibit fever relieving, pain relieving and anti - inflammatory effects, meanwhile, which had a progress in the treatment of tumor.
作者 高秀清
出处 《中国医院用药评价与分析》 2007年第1期20-22,共3页 Evaluation and Analysis of Drug-use in Hospitals of China
关键词 非甾体抗炎药 环氧酶-2抑制剂 临床应用 研究进展 non - steroidal anti - inflammatory drug (NSAID) epoxidase - 2 inhibitor clinical application research progress
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参考文献20

  • 1Vane JR.Towards a better aspirin[J].Nature,1994,36(2):215.
  • 2Ryn Jv,palret M.Clinical experience with cyclooxygenase-2 inhibitor[J].Inflam m Res,1999,48(2):247.
  • 3杨素平,陈锐.美洛昔康治疗骨关节炎的临床疗效[J].中国临床药学杂志,2004,13(1):37-38. 被引量:9
  • 4汪倪萍,丁长海,魏伟,徐建华,徐叔云.尼美舒利治疗类风湿关节炎的临床研究[J].中国药理学通报,2004,20(4):424-428. 被引量:13
  • 5Bensen w,Weaver A,Espinoza L,et al.Efficacy and safety of valdecoxib in treating the signs and symptoms of rheumatoid arthritis:a randomized,controlled comparison with placebo and naproxen[J].Rheumatology,2002,41(9):1 008.
  • 6Sikes DH,Agrawal NM,Zhao WW,et al.Incidence of gastro duodenal ulcers associated with valdecoxib compared with that of ibuprofen and dielofenac in patients with osteoarthritis[J].Eur J Castroeuterot Hepatol,2002,14(10):1 101.
  • 7Barton SF,Langeland FF,Snabes MC,et al.Efficacy and safety of intravenous parecoxib sodium in relieving acute postoperative pain following gynecologic laparotomy surgery.[J].Anesthesiology,2002,97(2):306.
  • 8Fricke J,Varkalis J,Zwillich S,et al.Valdecoxib is more efficacious than rofecoxib in relieving pain associated with oral surgery[J].Am J ther,2002,9(2):89.
  • 9Ahmad SR,Kortepeter C,Brinker A,et al.Renal failure associated with the use of celecoxib and rofecoxib[J].Drug Safay,2002,25(7):537.
  • 10施文,王永铭.环氧酶(COX)家族的生物学研究进展[J].中国药学杂志,2004,39(4):246-249. 被引量:11

二级参考文献88

  • 1张有成,王杉,张辉,梁斌,叶颖江.转录信号传导子和激活子3信号传导通路调控选择性环氧化酶2抑制剂抗结肠癌的机制[J].中华胃肠外科杂志,2004,7(5):404-406. 被引量:5
  • 2[15]Sheng H,Shao J,Morrow JD,et al.Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells[J].Cancer Res 1998,58:362~366.
  • 3[16]Hara A,Yoshimi N,Niwa M,et al.Apoptosis induced by NS-398,a selective cycloxygenase-2 inhibitor,in human colorectal cancer cell lines[J].Jpn J Cancer Res,1997,88:600~604.
  • 4[17]LiM,Lotan R,Levin B,et al.Aspirin induction of apoptosis in esophageal cancer:a potential for chemoprevention[J].Cancer Epidemiol Biomarkers Prev 2000,9:545~549.
  • 5[18]Ding XZ,Tong WG,Adrian TE.Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells[J].Anticancer Res,2000,20:2625~2631.
  • 6[19]Hanif R,Pittas A,Feng Y,et al.Effects of nonsteroidal anti-inflammatory drugs on prolieration and on induction of apoptosis in colon cancer cells by a prostaglandinindependent pathway[J].Biochem Pharmacol,1996,52:237~245.
  • 7[20]Elder DJ,Halton DE,Hague A,et al.Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug:independence from COX-2 protein expression[J].Clin Cancer Res,1997,3:1679~1683.
  • 8[21]Zhang X,Morham SG,Langenbach R,et al.Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs(NSAIDs)on cyclooxygenase-null embryo fibroblasts[J].J Exp Med,1999,190:451~459.
  • 9[22]Masferrer JL,Leahy KM,Koki AT,et al.Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors[J].Cancer Res,2000,60:1306~1311.
  • 10[23]Nie D,Lamberti M,Zacharek A,et al.Thromboxane A(2)regulation of endothelial cell migration,angiogenesis,and tumor metastasis[J].Biochem Biophys Res Commun 2000,267:245~251.

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