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特异性神经元抗-Hu抗体临床诊断研究进展 被引量：3

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摘要 神经系统副肿瘤综合征（paraneoplastic syndrorne of nervous svstem,PNSNS）是由恶性肿瘤导致的一种复杂的神经系统综合征，包括副肿瘤性小脑变性（paraneoplastic cerebellar degeneration，PCD）、副肿瘤性感觉神经元病（paraneoplasticcsensory neuropathy，PSN）、副肿瘤性脑脊髓炎（paraneopolastic encepalomyelitis，PEM）等。近年研究发现，以抗-Hu抗体为代表的一类特异性神经元抗核抗体。目前已成为诊断PNSNS高度特异和灵敏的指标,尤其在PNSNS伴发小细胞肺癌（small cell lung cencer,SCLC）等恶性肿瘤的患者血清、脑脊液（CSF）中，已成为一种公认的高度特异的标志物。同时，对多种原发性恶性肿瘤。如SCLC、卵巢癌、乳腺癌、前列腺癌、淋巴瘤等具有早期预测作用。目前在欧美国家,特异性神经元抗核抗体检测已广泛应用于临床实践和科学研究中，而在我国仍处于早期零散应用阶段。本文旨在对抗-Hu抗体临床诊断的发展和应用作一简要综述。
作者 王刚 任汝静 陈齐鸣 陈生弟
机构地区 上海交通大学医学院附属瑞金医院神经科 神经病学研究所 安徽蚌埠医学院附属医院神经内科
出处 《诊断学理论与实践》 2007年第1期63-65,共3页 Journal of Diagnostics Concepts & Practice
关键词 神经系统副肿瘤综合征 抗-Hu抗体 Hu抗原
分类号 R741.04 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献23

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二级参考文献18

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共引文献17

同被引文献41

  • 1黄云超.肺癌诊疗技术新进展[J].昆明医科大学学报,2012,33(5):1-3. 被引量：4
  • 2闻建民,徐庆云.肺癌的影像学检查方法进展与选择[J].浙江临床医学,2006,8(1):99-100. 被引量：1
  • 3Bruley Des Varannes S.,Chevalier J.,Pimont S.,M. Neunlist,程妍(译),陈云茹(校).失弛缓症患者血清可改变正常人胃底肠肌间神经丛化学信号和NO介导的反应[J].世界核心医学期刊文摘（胃肠病学分册）,2006,2(8):34-35. 被引量：4
  • 4Nikolina Vlatkovi?,Mark T. Boyd,Carlos P. Rubbi.Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy[J]. Cellular and Molecular Life Sciences . 2014 (5)
  • 5Cecilie Totland,Ming Ying,Mette Haugen,Kibret Mazengia,Anette Storstein,Jan Aarseth,Aurora Martinez,Christian Vedeler.Avidity of onconeural antibodies is of clinical relevance[J]. Cancer Immunology, Immunotherapy . 2013 (8)
  • 6María Fátima Ladelfa,Leticia Yamila Peche,María Fernanda Toledo,Julieta Eva Laiseca,Claudio Schneider,Martín Monte.Tumor-specific MAGE proteins as regulators of p53 function[J]. Cancer Letters . 2012 (1)
  • 7Nicole Hartwig Trier,Paul Robert Hansen,Christian A. Vedeler,Finn Engeborg Somnier,Gunnar Houen.Identification of continuous epitopes of HuD antibodies related to paraneoplastic diseases/small cell lung cancer[J]. Journal of Neuroimmunology . 2011 (1-2)
  • 8Sebastian Maier,Theresia Wilbertz,Martin Braun,Veit Scheble,Markus Reischl,Ralf Mikut,Roopika Menon,Pavel Nikolov,Karen Petersen,Christine Beschorner,Holger Moch,Christoph Kakies,Chris Protzel,Jürgen Bauer,Alex Soltermann,Falko Fend,Annette Staebler,Claudia Lengerke,Sven Perner.SOX2 amplification is a common event in squamous cell carcinomas of different organ sites[J]. Human Pathology . 2011 (8)
  • 9Jeffrey A. Tsou,Meleeneh Kazarian,Ankur Patel,Janice S. Galler,Ite A. Laird-Offringa,Catherine L. Carpenter,Stephanie J. London.Low level anti-Hu reactivity: A risk marker for small cell lung cancer?[J]. Cancer Detection and Prevention . 2008 (4)
  • 10Anette Storstein,Christian A. Vedeler.Paraneoplastic Neurological Syndromes And Onconeural Antibodies: Clinical And Immunological Aspects[J]. Advances in Clinical Chemistry . 2007

引证文献3

诊断学理论与实践
2007年 第1期

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