维生素E对维持性血液透析患者氧化应激及微炎症状态的影响被引量：16

The effect of vitamin E supplementation on oxidative stress and microinflammation state in patient with MHD.

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摘要目的研究抗氧化剂维生素E对维持性血液透析(MHD)患者氧化应激及微炎症状态的影响。方法选择2005年1月至2006年3月在重庆医科大学第二附属医院血液净化中心透析时间超过3个月的MHD患者58例,口服维生素E400mg/d,服药6周,观察用药前后血浆中维生素E及血浆丙二醛(MDA)、循环晚期氧化蛋白产物(AOPP)、过氧化物歧化酶(SOD)、谷胱苷肽过氧化物酶(GSH-PX)等氧化指标以及血浆高敏C-反应蛋白、白介素-6(IL-6)、白介素10(IL-10)、肿瘤坏死因子-α(TNF-α)等炎症指标的变化。选择20名健康者作对照组。结果给予维生素E治疗后,患者MDA、AOPP较治疗前明显降低(P<0.01),维生素E、SOD活性、GSH-PX活性较治疗前升高(P<0.01),炎症指标CRP和TNF-α较治疗前明显降低(P<0.01),IL-6变化较治疗前差异无显著性。结论口服大剂量维生素E(400mg/d)可以改善血液透析患者的氧化应激状态并具有抗炎效应,短期应用大剂量维生素E未见明显副反应。 Objective To investigate the oxidative stress, microinflammation and their relationship in patients with MHD （maintenance hemodialysis）and to evaluate the effect and safety of vitamin E supplementation in patients with MHD. Methods Fifty-eight patients with MHD and 20 healthy volunteers were involved in this study. The patients were administered 400 mg/d of vitamin E for 6 weeks. The levels of oxidative vitamin E（ Vit E） , malondialdehyde（MDA）, advanced oxidation protein product （ AOPP）, superoxide dismutase （ SOD）, activity of glutathione peroxidase （ GSH-PX ）, microinflammation cytokines C-reactive protein （ CRP）, interleukin-6 （ IL-6 ）, interleukin-10 （IL-10） and tumor necrosis factor （TNF-α） in plasma were measured at the beginning and the end of administering Vit E. Results 400 mg/d of Vit E supplementation decreased the levels of plasma AOPP, M DA ,CRP,TNF-α（P 〈 0. 01 ）, while the levels of Vit E, SOD, GSH- PX were increased （ P 〈 0. 01 ）. There was no significant change on plasma levels of IL-6. Conclusion There are oxidative stress and microinflammation state in patients with MHD. 400 mg/d of Vit E ameliorates oxidative stress and microinflammation state without apparent side effect,although farther observation are needed.

作者冯利平张玲钟玲朱冬菊刘玲

机构地区重庆医科大学第二附属医院肾内科

出处《中国实用内科杂志》 CAS CSCD 北大核心 2007年第3期215-217,共3页 Chinese Journal of Practical Internal Medicine

关键词维生素E 血液透析氧化应激微炎症 Vitamin E Hemodialysis Oxidative stress Microinflammation

分类号 R5 [医药卫生—内科学]

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