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骨髓间充质干细胞移植治疗缺血性心脏病研究进展 被引量:2

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摘要 心肌梗死(myocardialinfarction,MI)是由于冠状动脉循环改变引起冠状血流和心肌需求之间不平衡而导致的心肌损害,是临床上一种严重的缺血性心脏病(ischemicheartdisease,IHD)。坏死后的心肌细胞逐渐被瘢痕组织所取代,由于瘢痕组织缺乏弹性,难以满足心脏收舒功能的要求,为代偿损失心肌细胞的功能,心脏逐渐发生退行性左心室重塑,心功能下降,最终导致充血性心力衰竭(congestiveheartfailure,CHF)。临床药物和介入治疗虽可以改善症状,但却不能挽回受损的心肌细胞。心脏移植虽可以从根本上解决心室重构问题,但因为其供体受限,医疗费用太高而难以广泛应用。近来的研究表明,心肌细胞也具有再生能力,在发生MI后,心肌细胞也可以发生分裂和增殖。
出处 《中国心血管病研究》 CAS 2007年第3期232-234,共3页 Chinese Journal of Cardiovascular Research
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参考文献18

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