摘要
目的调查肿瘤化疗患者深部真菌感染现状,加强感染的防治。方法回顾调查2003年1月-2005年12月,102例肿瘤化疗患者并真菌感染的临床资料,对真菌感染的危险因素、真菌的种类及其耐药性进行单因素分析。结果102例真菌感染以下呼吸道为主,占61.8%,其次为口腔,占16.7%,各种感染性标本培养出真菌102株,以白色念珠菌为主,占71.6%,其次为热带念珠菌,占14.7%,白色念珠菌对氟康唑敏感率最高,为96.2%,对咪康唑的敏感率最低,为78.4%。结论本组肿瘤化疗患者发生真菌感染的原因与原发肿瘤疾病、患者年龄、外周血白细胞数、抗菌药物使用及化疗次数等因素密切有关。
OBJECTIVE To investigate the pattern of fungal isolates from hospital-acquired infection in tumor patients after chemotherapy. METHODS The clinical information of fungus isolates from 102 tumor patients after chemotherapy was investigated. We analyzed the risk factors, species and drug-resistance of isolates. RESULTS The lower respiratory tract and mouth infection accounted for 61.8% and 16.7% in 102 cases with fungal infection and 102 isolates were isolated from various clinical specimens. Among above 102 isolates, Candida albicans and C. tropicalis accounted for 71.6% and 14.7%. The resistant rate of C. albicans to fluconazole and miconazole were 96. 2% and 61.4%, respectively. CONCLUSIONS Hospital-acquired infection resulted from fungi in tumor patients after chemotherapy is related to primary tumor,age,the amount of white cell and use of antibiotics.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2007年第2期160-162,共3页
Chinese Journal of Nosocomiology
关键词
肿瘤患者
化疗
真菌
医院感染
Tumor patients
Chemotherapy
Fungus
Hospital-acquired infection
