摘要
目的：单用依那普利（Ｅｎａ）与联用硝苯地平控释片（ｎｉｆ－ＣＲ），治疗老年原发性高血压疗效比较。方法：单用Ｅｎａ组３６例（男性２４例，女性１２例，年龄６７±ｓ１３ａ），剂量５～２０ｍｇ，ｐｏ，ｂｉｄ，平均剂量为２４±８ｍｇ／ｄ；联用组５０例（男性３２例，女性１８例，年龄６８±５ａ）。采用Ｅｎａ片２．５～１０ｍｇ，ｐｏ，ｂｉｄ，平均剂量为１２±４ｍｇ，加用Ｎｉｆ－ＣＲ片３０ｍｇ，ｐｏ，ｑｄ。疗程均４ｗｋ．结果：单用组与联用组降压显效率分别为４２％与７８％，总有效率分别为７２％与９４％，组间比较Ｐ＜０．０１。２组不良反应轻微。结论：联用组疗效优于单用组。
AIM :To compare the effectiveness between enalapril and enalapril combined with control-released nifedipine(Nif-CR) in treating primary hypertension in aged patients. METHODS:Enalapril group of 36 patients(M 24,F 12;age 67 ±s 13 a)received enalapril 5-20 mg(24 ±8 mg/d) po,bid for 4 wk.The combination group of 50 patients(M 32, F 18;age 68±5 a) received enalapril 2.5-10 mg(12±4 mg/d)po,bid and Nif-CR 30mg/d,po,for 4 wk.RESULTS:After treatment the markedly effective rates of enalapril group and the combination group were 42% and 78% respectively;their total effective rates were 72% and 94% respectively (P<0.01).The adverse reactions of 2 groups were mild.CONCLUSION:The combination group is better than enalapril group in treating primary hypertension in aged patients.
出处
《新药与临床》
CSCD
北大核心
1996年第5期273-275,共3页
关键词
依那普利
硝苯地平
高血压
药物疗法
enalapril
nifedipine
hypertension
delayed-action preparation
combination drug therapy
