摘要
目的探讨无症状心肌缺血与心绞痛患者血浆内皮素-1变化的临床意义。方法采用放射免疫法测定ET-1含量,并查心电图及超声心动图。结果SMI与对照组无显著差异,其病变程度与ET-1变化呈零相关,AP组ET-1明显高于对照组,其病变程度与ET-1变化呈正相关,治疗后ET-1降至正常水平,AP非发作期ET-1亦有显著差异。结论结果显示血浆ET-1水平可能在冠心病心肌缺血类型和临床症状等方面起作用。
Objective To study the concentration changes and significance of endothelin（ET-1）in the patients with silent myocardial ischemia （SMI）and angina pectoris （AP）. Methods Radiation immunity technique and two-dimensional echocardiography are adopted. Results There was no significant difference between SMI and normal control, and no correlation between the degrees of pathological changes in SMI and the changes of ET-1 conceritration. ET-1 concentration in AP was higher obviously than in control,and there was a positive correlation between the degrees of pathological changes in AP and the changes ET-1 concentration. ET-1 concentration in AP decreased to control level after treatment. There was a significant difference of ET-1 concentration in attack period and unattack period of AP. Conclusions It was indicated that ET-1 level may have effects on the types and clinical symptoms of myocardial ischemia of coronary heart disease.
出处
《青岛医药卫生》
2007年第1期6-6,44,共2页
Qingdao Medical Journal
关键词
心肌缺血
无症状
心绞痛
内皮素-1
myocardial ischemia, silent
angina pectoris, Endothelin-1
