摘要
髓系细胞表达的触发受体-1(TREM-1)是新近确认的一个与炎症相关的免疫球蛋白超家族成员,表达于中性粒细胞、成熟的单核细胞、巨噬细胞表面。多种细菌性成分能使细胞表面的TREM-1表达增加,后者与Toll样受体协同作用,激发炎症因子的产生。最新的研究发现,感染过程中一种可溶性TREM-1(sTREM-1)可释放进入体液,并且与多种疾病如肺炎、细菌性脑膜炎、炎症性肠病密切相关,成为一种早期诊断炎症性疾病的新指标。
The triggering receptor expressed on myeloid cells （TREM）-1 is a recently identified molecule involved in the inflammatory response. It belongs to the immunoglobulin superfamily and is expressed on the surface of neutrophils, mature monocytes, and macrophages. The engagement of TREM-1 synergizes with the Toll-like receptors signaling pathway in amplifying the inflammatory response mediated by several microbial components. Besides its membranous form, a soluble counterpart of TREM-1 is specifically released during several infectious processes. The measurement of that soluble form in biological fluids may be useful as a early diagnostic marker, especially during pneumonia, bacterial meningitis and inflammatory bowel disease （IBD）.
出处
《国际病理科学与临床杂志》
CAS
2007年第1期73-76,共4页
Journal of International Pathology and Clinical Medicine
关键词
髓系细胞触发受体-1
感染
炎症
triggering receptors expressed on myeloid cells-1 （TREM-1）
infection
inflammation
