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趋化因子及其受体与炎症性肠病 被引量：3

Chemokines and their receptors in inflammatory bowel disease
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摘要 炎症性肠病(IBD)包括溃疡性结肠炎(UC)和克罗恩病(CD),是一类慢性反复发作的肠道非特异性炎症性疾病,其病因和发病机制尚未完全阐明,免疫反应异常是其重要特点。趋化因子是炎症反应中白细胞募集的最重要的调节因子,很多趋化因子参与IBD的发病。此文就近年来趋化因子及其受体与炎症性肠病的研究进展作一综述。 Inflammatory bowel diseases（IBD） represent chronic and recurrent inflammatory disorders of the gastrointestinal tract,which include ulcerative colitis（UC） and Crohn disease（CD）, characterrized by abnormal immune reaction. The pathogenesis of IBD is still unknown. Chemokines have emerged as the most important regulators of leukocyte trafficking during inflammation. Many chemokines have been implicated in the pathogenesis of IBD. This article reviews recent advances on the role of chemokines and their receptors in IBD.
作者 丁炎波 邹开芳
机构地区 常州市第一人民医院 华中科技大学附属协和医院消化内科
出处 《国际消化病杂志》 CAS 2007年第1期44-46,共3页 International Journal of Digestive Diseases
关键词 趋化因子 趋化因子受体 炎症性肠病 Chemokine Chemokine receptor Inflammatory bowel disease
分类号 R574 [医药卫生—消化系统]
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参考文献17

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同被引文献18

  • 1欧阳钦,胡品津,钱家鸣,郑家驹,胡仁伟.对我国炎症性肠病诊断治疗规范的共识意见[J].胃肠病学,2007,12(8):488-495. 被引量：751
  • 2Yajima N,Kasama T,Isozaki T,et a1.Elevated levels of soluble fractalkinein active systemic lupus erythematosus:potential involvement inneuropsychiatric manifestations[J].Arthritis Rheum,2005,52(6):1670-1675.
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  • 4Bjerkeli V,Damas JK,Fevanq B,et al.Increased expression of fractalkine(CX3CLl)and its receptor.CX3CR1 in Wegenegs granulomatosispossible role in vascular inflammation[J].Rheumatology,2007,46(9):1422-1427.
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国际消化病杂志
2007年 第1期

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