摘要
目的评估不同透析剂量对持续性非卧床腹膜透析（CAPD）患者生存质量的影响，以寻求更合理的符合中国人特点的腹膜透析剂量。方法将稳定的CAPD3个月的患者随机分为2组，即低剂量组（2L／次，3次／天）和常规剂量组（2L／次，4次／天）。每半年对两组患者进行生存质量、营养状态、炎症状态、残余肾功能、严重心血管事件发生率进行评估，持续2年，比较两组之间的差异，使用KDQOL-SFTM1．2生存质量表进行调查，根据Hays提供的方法进行评分，SPSS10．0软件包分析数据。结果①随着透析时间的延长，患者的生存质量评分逐渐增加；②低剂量组与常规剂量组患者的KDTA和SF-36总分无显著性差异，在KDTA的4个分支领域及SF-36的2个分支领域评分高于常规剂量组；③两组患者的营养状态、全身微炎症状态、高血压的控制、严重心血管事件的发生率无明显差别；④低剂量组残余肾功能优于常规剂量组。结论低透析剂量较常规透析剂量能更好的保护残余肾功能，值得推荐。
Objective To evaluate the quality of life （QoL） in CAPD patients with different dialysis doses, and to find out a optimal dialysis dose for Chinese. Method 63 patients treated with CAPD for three months were randomly divided into two ＂groups： low-dose dialysis group（6L/d） and routine, usual-dose dialysis group（8L/d）. The QoL,nutritional status,inflammation and residual renal function of the patients in both groups were evaluated every six months. QoL was obtained using KDQOL-SFTM 1.2 questionnaire and scored according to Ron Hays Score Criterion. Results （1）The score of QoL of the patients kept increasing after start of dialysis. （2）There were no significant differences in KDTA and SF-36 total scores between two groups. In some areas of KDTA （cffects of kidney disease.burden of kidney disease.quality of social interaction and sexual function） and SF-36 （emotional well-being and energy/fatigue） the scores of low-dose group were better than routine dose group. （3） There were no significant differences in nutritional status, inflammation, the control of hypertension and the incidence of serious cardiac disease between two groups. （4）The reservation of residual renal function in low-dose group was better than routine-dose group. Conclusions Compared with routine- dose （8L/d）, Low dose （6L/d） dialysis has better protective effect on residual renal function.
出处
《临床肾脏病杂志》
2007年第1期8-10,共3页
Journal Of Clinical Nephrology
关键词
腹膜透析
生存质量
残余肾功能
Peritoneal dialysis
Quality of life,Residual renal function
