摘要
目的:对齐墩果酸固体脂质纳米粒的制备工艺和含量测定方法进行研究,并对其质量进行评价.方法:采用薄膜超声分散法制备齐墩果酸固体脂质纳米粒,并对其包封率、形态等性质进行研究.结果:制得齐墩果酸固体脂质纳米粒形态均匀圆整、粒径范围为(62.0±10.3)nm,包封率为98.29%,载药量为8.17%.结论:选择薄膜超声分散法制备齐墩果酸固体脂质纳米粒方法可行,为开发齐墩果酸新型注射制剂提供了实验依据.
AIM： To prepare the oleanolic acid-loaded solid lipid nanoparticles （OA-SLN）, determine the content of oleanolic acid in OA-SLN, and evaluate its quality. METHODS： OA-SLN were prepared by film-ultrasound dispersion technique. The encapsulation efficiency and appearance of solid lipid nanoparticles were studied. RESULTS ： The appearance of prepared solid lipid nanoparticles was regular with the diameter being （62.0 ± 10.3） nm, the encapsulation efficiency was 98.29% and the loading rate was 8. 17%. CONCLUSION： The selected preparation technique of OA-SLN is rational and practicable. It provides experimental evidence for developing a new oleanolic acid injection.
出处
《第四军医大学学报》
北大核心
2007年第5期472-474,共3页
Journal of the Fourth Military Medical University
关键词
齐墩果酸
固体脂质纳米粒
质量评价
oleanolic acid
solid fipid nanoparticles
quality evaluation
