摘要
目的:调查我院抗菌药相关性腹泻发生情况。方法:对2005年16月44例住院患者的抗菌药相关性腹泻进行回顾性调查和分析。结果:抗菌药相关性腹泻占同期感染性腹泻的41.5%。以老年患者、肝肾功能异常患者为主。常见致病药物有:左氧氟沙星、头孢哌酮/舒巴坦、克林霉素等,均为静脉滴注给药。抗菌药相关性腹泻最快出现在用药第2天,经抗真菌药物、微生态制剂治疗7d后患者症状消失。结论:静注抗菌药物可引致腹泻,因此,医师临床应用抗菌药物时应加以注意,特别是对老年及肝肾功能不全患者,以避免药源性腹泻的发生。
Objective： To investigate the situation of antibacterial-associated diarrhea occurring in our hospital. Methods： Forty-four patients with antibacterial-associated diarrhea in our hospital were investigated and analysed retrospectively from January to June in 2005. Results： The antibacterial-associated diarrhea accounted for 41.5% of infectious diarrhea. Most of patients with antibacterial-associated diarrhea were elderly patients and patients with liver or renal dysfunction. The common causative agents were levofloxacin, cefoperazone / sulbactam, clindamycin, and so on. All these agents were given by intravenous infusion. The initial time of onset of diarrhea occurred 2 days after the start of antibacterial drug therapy. The symptoms of diarrhea disappeared after 7 days of treatment with antifungal agents and microecological preparations. Conclusion： Intraveously administered antibacterial drugs may cause diarrhea; therefore, physicians should be care of using these drugs in treating patients, especially in elderly patients and patients with liver or renal dysfunction, in order to avoid the occurrence of diarrhea.
出处
《药物不良反应杂志》
2007年第1期24-27,共4页
Adverse Drug Reactions Journal
关键词
抗菌药
腹泻
antibacterials
diarrhea
