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食管癌中Cox-2与p53表达及相关意义 被引量：4

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摘要 目的探讨食管癌中Cox-2与p53蛋白表达与临床病理参数之间的关系,并探讨二者的相关性及可能机制。方法采用免疫组化S-P法检测52例食管鳞状细胞癌和10例正常食管鳞状上皮中Cox-2与p53蛋白的表达。结果食管癌中Cox-2、p53蛋白阳性表达率分别为76.9%(40/52)、82.7%(43/52),而正常食管黏膜表达均为阴性;且Cox-2的高表达与食管癌分化程度、淋巴结转移情况呈相关(P<0.05);p53蛋白的过表达与肿瘤浸润深度、淋巴结转移呈正相关;Cox-2表达阳性组p53表达明显高于阴性组(P<0.05)。结论在食管癌发生发展中Cox-2、p53可能起重要作用,Cox-2通过使抑癌基因p53失活而促进肿瘤的发生发展。
作者 陈玉芳 万美珍 史永娟
机构地区 江苏省常州市肿瘤医院病理科
出处 《现代肿瘤医学》 CAS 2007年第3期360-362,共3页 Journal of Modern Oncology
关键词 食管鳞癌 环氧合酶-2 P53蛋白 免疫组化
分类号 R735.1 [医药卫生—肿瘤]
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参考文献10

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现代肿瘤医学
2007年 第3期

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