摘要
治疗性单克隆抗体的快速发展在人类以肿瘤为主的多种疾病的治疗方面发挥至关重要的作用。为了降低鼠源抗体引起的超敏反应,治疗性单克隆抗体已由改型抗体,人源化抗体发展到全人抗体。随着生物技术的不断发展,相信人源化单克隆抗体的前景会越来越广泛。
The rapid development of therapeutic McAbs plays a crucial effect in treating many kinds of human diseases, especially in treating tumor. Therapeutic mAbs has developed from reshaping antibody and humanized antibody to fully human antibody in order to lower supersensitivity resulting from meuse antibody. With the going forward of biotechnology,humanized antibody will has a more and more wide perspective.
出处
《医学综述》
2007年第5期325-327,共3页
Medical Recapitulate
基金
国家十五科技攻关资助项目(2001BA703B11)
关键词
单克隆抗体
人源化
人源化抗体
治疗
Monoclonal antihody
Humanize： Humanized antibody： Therapy
