摘要
目的研究环氧合酶（COX）-2在Barrett食管（BE）及其相关疾病中的表达情况及其意义。方法应用免疫组化S-P法分别测定59例BE，5例食管腺癌，5例重度反流性食管炎（RE）患者，10例食管黏膜正常者组织中COX-2的表达情况。数据采用等级分组秩和检验。结果COX-2在BE中的阳性率为86．4％，在食管腺癌中为5／5例，与正常食管（3／10例）和RE（2／5例）比较差异均有统计学意义（P＜0．05）。长段BE黏膜中COX-2表达（100．0％）较短段BE（80．9％）高（P＜0．05）。不同类型BE（全周型、舌型和岛型）、不同程度肠化生（轻度、中度、重度）COX-2的表达差异均无统计学意义（P＞0．05）。结论COX-2在BE和腺癌组织中的表达显著增高，长段BE黏膜中COX2的表达较短段BE为高。
Objective To investigate the expression of cyclooxygenase （COX）-2 in Barrett＇ s esophagus（BE） and their clinical significance. Methods The expression of COX-2 was measured by im munohistochemical staining（S-P method） in 59 patients with BE, 5 with esophageal adenocarcinoma, 5 with severe reflux esophagitis（RE） and 10 with normal esophageal epithelium. Results The rate of COX-2 expression was 86.4% in BE and 5/5 in esophageal adenocarcinoma. It was significant higher than those in normal control （3/10） and RE（2/5） （P〈0.05）. The expression of COX-2 in long segment of BE was 100%, which was significantly higher than that in short segment BE （80.9%, P 〈 0.05）. But the expression of COX-2 was no statistical differences between different types of BE （circumference, island, and tongue）, and different degrees of intestinal metaplasia in BE （P〉0.05）. Conclusion There were significantly increased the expression of COX-2 in BE, especially in long segment of BE and esophageal adenocarcinoma.
出处
《中华消化杂志》
CAS
CSCD
北大核心
2007年第2期87-89,共3页
Chinese Journal of Digestion
基金
本课题系上海市重点学科建设资助项目（Y0205）
