摘要
目的探讨大小Y染色体核型的临床意义。方法用外周血淋巴细胞培养、G显带技术分析。结果117例大Y染色体患者中生精异常17例(包括少精、无精)、外生殖器发育不良11例、其妻习惯性流产36例、胎停育35例、有其它不良孕产史18例(包括出生缺陷、死胎、早产等);57例小Y染色体患者中生精异常14例、外生殖器发育不良8例,其妻子习惯性流产15例、胎停育9例、有其它不良孕产史11例。结论Y染色体的变异均会不同程度地导致临床效应。
Objective： To probe into clinical significance of long or short Y chromosome. Methods ： 117 cases of large Y chromosome and 54 cases of shori Y chromosome blood samples of patients were examined by G banding cytogenetic analysis. Resuits： Among 117 cases of large Y chromosome polymorphism patients, 17 cases were found abnormal spermatogenesis, 11 cases were found hypoplasis of external genital, 36 cases whose wives had recurrent miscarriage, 35 cases showed early embryonic death, and 18 cases had other different abnormal procreating. Among 57 cases of short Y chromosome patients, 14 cases had abnormal spermatogenesis, 8 cases had hypoplasis of external genital, 15 cases whose wives had recurrent miscarriage, 9 cases had early embryonic death, and 11 cases had other different abnormal procreating. Conclusion： Long or short Y chromo- some may lead to some different clinical effects.
出处
《中国计划生育学杂志》
北大核心
2007年第2期105-107,共3页
Chinese Journal of Family Planning
