摘要
目的:探讨漏芦多糖对小鼠免疫反应的影响及作用机制。方法:分别用绵羊红细胞(SRBC)和卵清蛋白为抗原给小鼠注射后,将漏芦多糖分为3个剂量(50,100,200mg.kg-1.d-1)灌服小鼠7d,加强免疫后,检测相应抗体生成水平和血清中白细胞介素-2(IL-2),γ-干扰素(IFN-γ)生成水平。结果:中剂量给药组SRBC抗体生成水平和卵清抗体生成水平,IL-2,IFN-γ激发水平均显著高于对照组(P<0.05)。结论:漏芦多糖对正常小鼠机体免疫有增强作用。
Objective： To study the effects of Rhaponticum uniforum polysaccharide on immune function in normal mice and the underlying mechanism. Method： SRBC and ovalbumin were employed as antigens to be injected to mice, respectively. Three doses of R. uniforum polysaccharide （50, 100,200 mg · kg^- 1· d^-1） were given orally for seven days. After the secondary immunization, the level of corresponding antibody and the concentration of serum IL-2, IFN-γ, were determined. Result： The levels of antibodies （ anti-SRBC and anti-ovalbumin） and cytokines （IL-2 and IFN-γ） in median dose group of R. uniforum polysaccharide were all significantly higher than those in control groups （P 〈0. 05）. Conclusion： R. uniforum polysaccharide could enhance the immune function in normal mice.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第5期433-435,共3页
China Journal of Chinese Materia Medica
基金
辽宁省教育厅项目(202200953)
关键词
漏芦多糖
免疫
IL-2
IFN-Γ
Rhaponticum uniforum polysaccharide
immunity
IL-2
IFN-γ
