摘要
应用免疫组化LSAB法，对34例尸检心脏标本，进行心肌细胞内纤维连接蛋白用于早期心肌梗死死后诊断的研究。其中尸检及组织学证实心肌梗死5例，其心肌细胞内纤维连接蛋白均呈阳性。冠状动脉有硬化或冠状动脉口狭窄的可疑心肌梗死18例，其中15例心肌细胞内纤维连接蛋白阳性。非心性死亡对照组11例，心肌细胞内纤维连接蛋白均呈阴性。实验表明，心肌细胞内纤维连接蛋白免疫组化观察在急性心肌梗死，尤其是早期心肌梗死死后诊断上具有重要价值，为早期心肌梗死的死后诊断提供了一个实用方法。
Immunohistochemical study of fibronectin (FN ) was first per formed on 34 autopsy hearts for postmortem diagnosis of early myocardial infarction with LSAB-method. The results showed that FN was positive in cardiomyocytes of all 5 difinite myocardial infarctions. Among 18 suspected myocardial infarctions, FN was positive in 15 cases. However,FN was negative in cardiomyocytes of all 11 non-cardiac death controls. These facts suggest that FN in cardiomyocytes is a re1iable marker of acute my-ocardial infarction, especially of early myocardial infarction, and could be used as a new, sensitive method for the postmortem diagnosis of acute myocardial infarction.
出处
《中国法医学杂志》
CSCD
1996年第1期14-17,共4页
Chinese Journal of Forensic Medicine
关键词
早期
心肌梗死
纤维连接蛋白
免疫组化
Early myocardial infarction
Fibronectin
Immunohistochemistry
LSAB-method
