摘要
单核苷酸多态性是指在基因组水平上单个核苷酸变异引起的一种DNA序列多态性。因其具有密度高,遗传稳定,易于进行自动化、规模化分析等优势它已成为第三代分子标记,因此其检测技术也在近几年得到了快速的发展。将对未知单核苷酸突变位点的检测方法和已知单核苷酸突变位点的检测方法这两部分的研究进展作一综述。
Single nucleotide polymorphism （SNP）is a novel set of polymorphism based on the single nucleotide variations at the genomic level. As it have several advantages such as high density,hereditary stability and easy to be detected automaticaly and largely,it has become the third generation genetic marker. The methods for SNP detection were renewed rapidly and developed fast in past few years. This paper is summarized the detection methods of known and unknown SNP site.
出处
《生物技术通报》
CAS
CSCD
2006年第6期64-67,共4页
Biotechnology Bulletin
基金
国家863计划内蒙古白绒山羊舍饲繁育关键技术的研究计划资助(编号:200AA242061)
关键词
单核苷酸多态性
检测技术
突变住点
Single nucleotide polymorphism
Detection methods
Mutation site
