摘要
[目的]某大学连续16年新生入学体检发现乙型肝炎表面抗原携带率在8%～17%之间。属于乙肝感染的高发状态。为探讨在大学生人群中注射乙肝疫苗控制乙肝病毒的传播的效果。[方法]连续16年在新生体检中对乙肝表面抗体阴性者进行乙型肝炎疫苗0,1,6程序注射,还对一年一度体检的非新生群体中乙肝免疫无应答者及低应答者进行再免疫。[结果]抽检近3年该大学学生血清乙肝标志物,在校学生的抗-HBs水平保持在57.82%～78.24%之间,大学生乙肝疫苗免疫前后抗体阳性的覆盖率有很大的差别,免疫后大学生的抗体阳性的覆盖率大幅提高,经统计学处理,P﹤0.005。接种疫苗者无发现乙型肝炎新发病例。[结论]通过对大学生进行乙肝疫苗接种效果分析。说明在大学生青年人群中进行乙肝疫苗接种,对于控制乙肝高流行状态,减少我国乙肝感染带来的巨大经济损失有着重要的意义。
[Objective] To diseuss the immunity effect of hepatitis B vaccine among freshmen. [Method] The new students with negative HBsAb received a regular vaccine of hepatitis B injection. Person with no immune response or low level immune response were found out by medical examination annually and received vaccine again. [ Results] The positive rate of HBsAb among undergraduates varied from 57.82% to 78.24% by random sampling detection in recent 3 years, apparently higher than that before immunization （P 〈 0.005） . No new case of hepatitis B was reported after immunization. [Conclusion] Popularized vaccination of hepatitis B in undergraduates will be helpful to control the epidemic of hepatitis B, which has great significance to lower the economic losses bronght by the hepatitis B infection.
出处
《现代预防医学》
CAS
北大核心
2007年第4期840-841,共2页
Modern Preventive Medicine
