摘要
[目的]观察长春瑞滨(盖诺)联合顺铂化疗方案治疗晚期乳腺癌的近期临床疗效与毒副反应。[方法]运用盖诺+顺铂联合化疗方案治疗晚期乳腺癌共40例,连续治疗2周期后评价疗效与毒副作用,疗效及毒性判断参照WHO标准。[结果]有效率为55.0%,其中CR(完全缓解)1例,PR(部分缓解)21例,SD(稳定)13例,PD(进展)5例。主要毒副反应为胃肠道反应和骨髓抑制。[结论]长春瑞滨联合顺铂化疗方案对晚期乳腺癌有较好的疗效,毒副反应可以耐受,可作为晚期乳腺癌患者的二线治疗方案,值得临床推广。
[Objective] To evaluate the effect and toxicity of Vinorelbine-Cisplatin combination chemotherapy in treatment of advanced breast cancer. [Methods] 40 advanced breast cancer patients were treated with Vinorelbine-Cisplatin combination chemotherapy. After two treatment cycles, the effect and toxicity were measured according to the WHO standard. [ Resuits] The response rate was 55.0%. 1 of 40 had complete response. 21 had partial response. 13 had stable disease. 5 had progressive disease. The main toxicity and side effect was bone marrow depression and gastrointestinal tract discomfort. [Conclusion] The Vinorelbine-Cisplatin combination chemotherapy were effective to treat advanced breast cancer, and the toxicity and side effect can be tolerated. It can be the second-line in treatment of advanced breast cancer, and worth using in clinical cure.
出处
《现代预防医学》
CAS
北大核心
2007年第4期879-880,882,共3页
Modern Preventive Medicine
