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四种方法尿微量白蛋白排出率对糖尿病肾病早期诊断价值评价 被引量:8

The evaluation of early diagnosis value of four methods of urinary albumin excretion rate for diabetic nephropathy
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摘要 目的评价晨尿、随机尿微量白蛋白(mALB)排出率诊断早期糖尿病肾病的可靠性。方法选择30例健康对照组和42例糖尿病患者,按24小时尿白蛋白排出率(UAER)分为无肾病组(UAER<30 mg/24 h)、早期肾病组(UAER30-300 mg/24 h)。所有受试对象留取24 h总尿量及晨尿、随机尿,检测尿mALB、尿肌酐。以UAER为对照,建立ROC曲线,评估晨尿直接法(MU)、晨尿肌酐矫正法(MC)、随机尿直接法(RU)、随机尿肌酐矫正法(RC)的诊断特异性和敏感性。结果晨尿、随机尿四种方法的截断点、敏感度、特异度、ROC曲线下面积是,MU法:14.0 mg/l、83%、82%、0.934;MC法:1.51 mg/l.g、85%、81%、0.915;SU法:20mg/l、75%、64%、0.616;SC法:2.1mg/l.g、82%、71%、0.862。结论晨尿mALB排出率对糖尿病肾病早期诊断价值优于随机尿;随机尿肌酐矫正法优于直接法,但是肌酐矫正法提高尿mALB假阳性。 Objective Objective To evaluate the validity of diagnosis value of random urinary mieroalbumin as a early diagnosis test for diabetic nephropathyMethods 30 eases of healthy control and 42 eases diabetic mellitus (DM) and divided into the none kidney disease(UAER 〈 30 mg/24 h) ,early period kidney disease(UAER30-300 mg/24 h) according to 24 hour urinary albumin excretion rate (UAER). All those cases took 24 hour urine and morning and random urine , and detecting ufiary mioroalbumin(mALB), uriary ereatine (Cr). UAER as gold standard,to develop receiver operating characteristics (ROC) curve of morning and random urine albumin excretion rate of 4 methods.Results The cutoff points ,sensitivity ,specificity ,ROC areas is Morning urine albumin (MU) : 14.0 mg/1,83%,82%,0.934 ,albumin/ereatine ratio (MC) : 1.51 rng/1.g,85%,81% ,0.915,Random urine albumin (RU) : 20 mg/1,75% ,64%,0.616,Random urine albumin/ereatine ratio (RC) : 2.1mg/1.g,82% ,71% ,0. 862. Condusion early diagnosis value of morning urine mALB superior to random urine and Random urine albumin/ereatine ratio (RC) superior to random urine albumin (RU) for Diabetic nephropathy.But urine albumin/ereatine ratio method increase false positive of uriary mALB.
出处 《中国实验诊断学》 2007年第3期327-329,共3页 Chinese Journal of Laboratory Diagnosis
关键词 糖尿病肾病 尿微量白蛋白 ROC曲线 晨尿 随机尿 Diabetic nephropathy Urinary mieroalbumin ROC curve Morning urine Random urine
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