摘要
目的评价血浆置换（PE）治疗系统性硬化症（SSc）的有效性和安全性。方法回顾性分析32例SSc患者用PE联合药物治疗后12个月的疗效，并与单纯药物治疗的41例患者进行对照。结果两组患者的齿距、双手握力、手指温度、改良Rodnan积分、肺弥散量，正常预计值、IgG在治疗后均有所改善，其中双手握力的改善最为显著，两组患者在治疗后1、3、6、12个月时每次较前次治疗差异均有统计学意义。治疗组与对照组同期疗效比较发现，治疗组在临床症状的改善方面显著优于对照组，并能够迅速降低尿蛋白及IgG，但在肺弥散功能的改善上两组比较差异无统计学意义。两组不良反应发生率差异无统计学意义。结论PE是一种治疗SSc的有效而安全的方法，值得临床应用和进一步研究。
Objective To evaluate the therapeutic effects and side-effects of plasma exchange （PE） treatment on systemic sclerosis. Methods Thirty-two cases of SSc treated by PE combined with medication were analyzed retrospectively from January 2000 to January 2006 compared with 41 cases treatd with medications only. Results Tooth spacing, holding power, the temperature of fingers, modified Rodnan thickness score, urinary protein, IgG were all improved in both groups after 1, 3, 6, 12 months and holding power was improved most significantly. The improvement of therapeutic group was more marked than control group in clinical presentations. The urinary protein and IgG decreased more quickly in the therapeutic group but there was no significant difference on lung diffusion function and side-effects in both groups. Conclusion PE is an effective and safe treatment for SSc and worthwile for application but further investigation is needed.
出处
《中华风湿病学杂志》
CAS
CSCD
2007年第3期176-178,共3页
Chinese Journal of Rheumatology
关键词
血浆置换
硬皮病
系统性
回顾性研究
Plasma exchange
Scleroderma systemic
Retrospective studies
