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人乳头状瘤病毒16型E6基因的小分子干扰RNA对子宫颈癌细胞生长的影响

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摘要 宫颈癌是一种常见的妇科恶性肿瘤。研究发现，人乳头状瘤病毒（HPV）是本病发生的一个重要病毒性致癌因子。大约80％的宫颈癌可检测到HPV16，其E6基因是致癌的关键基因，绝大多数宫颈癌HPV16、18E6癌蛋白通过泛素依赖的途径与p53蛋白结合，导致p53蛋白降解，致使细胞无限增殖。所以直接针对HPVE6基因的治疗可为宫颈癌患者提供有效的治疗方法。
作者 官立丽 彭芝兰 牛晓宇 周慧梅
机构地区 四川大学华西第二医院妇产科
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2007年第2期135-137,共3页 Chinese Journal of Obstetrics and Gynecology
基金 国家自然科学基金(30371483)
关键词 人乳头状瘤病毒16型 癌细胞生长 E6基因 小分子干扰RNA 子宫颈 HPV16 妇科恶性肿瘤 致癌因子
分类号 R737.33 [医药卫生—肿瘤]
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参考文献9

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二级参考文献20

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共引文献26

中华妇产科杂志
2007年 第2期

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