摘要
目的探讨连续性血液净化（CBP）对多器官功能障碍综合征（MOBS）患者C-反应蛋白（CRP）、血清淀粉样蛋白A（SAA）表达和T淋巴细胞亚群的影响。方法20例符合MOBS诊断标准的患者，均行CBP治疗。于CBP前，CBP后第1、3、5、7天清晨，分别测定CRP、SAA和T淋巴细胞亚群。结果CBP治疗后，存活组ClIP和SAA均呈下降趋势（P〈0．05或P〈0．01），CD3^＋、CD4^＋、CD4^＋/CD8^＋均有不同程度的升高（P〈0．05或P〈0．01），CD8^＋呈逐渐下降趋势（P〈0．05）。死亡组在CBP治疗前后ClIP和SAA均呈先下降后升高趋势，CD3^＋、CD4^＋、CD4^＋/CD8^＋均有不同程度的升高，CD8^＋在CBP治疗前后呈下降趋势。结论CBP可降低MOBS患者的CRP和SAA水平，维持T淋巴细胞亚群间的平衡。
Objective To investigate the effects of continuous blood purification on the levels of C-reactive protein （CRP）, serum amyloid A （SAA） and the percent of each T-lymphocyte subset in patients with multiple organ dysfunction syndrome （MODS）. Method Twenty patients with MODS in intensive care unit were scheduled for the treatment with CBP. All patients met the criteria of MODS. On mornings pre-CBP day, and at 1 day, 3 days, 5 days, 7 days after CPB, the levels of CRP, SAA and the percent of each T-lymphocyte subset were identified. Results The concentrations of CRP and SAA following CBP decreased gradually in survival patients, but there was an increasing trend in fatal patients. The percent of CD3^＋ , CD4^＋ , and ratio of CD4^＋/CD8^＋ increased and the cell percent of CD8^＋ decreased gradually in all patients. Conclusious CBP could decrease the concentrations of CRP and SAA, and maintain the balance of the subset-subset interactions among T-lymphocyte subsets in patients with MODS.
出处
《中华急诊医学杂志》
CAS
CSCD
2007年第3期279-282,共4页
Chinese Journal of Emergency Medicine
