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脑梗死疗效评价中替代指标的应用及其局限性 被引量:3

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摘要 替代指标是以流行病学、治疗学、病理生理等为基础,能够预测或最大可能地预测临床获益。据其定义,如果干预对替代指标有所改善,那么同时也意味着其对临床结局也有改善。在脑梗死的临床研究中,大多采用梗塞灶的面积、神经功能缺损等作为替代指标,虽然这些替代指标有时可以预测临床结局,但在实际的临床中,由于研究方法或干预的因果通道不同,采用这些替代指标可能存在一定的局限性。
作者 彭海丽 蒋萌
出处 《中药新药与临床药理》 CAS CSCD 2007年第2期165-167,共3页 Traditional Chinese Drug Research and Clinical Pharmacology
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