摘要
目的:探讨中药参麦注射液对新生大鼠缺氧缺血性脑损伤(HIBD)后学习和记忆能力的改善作用。方法:7日龄SD大鼠随机分为参麦注射液干预组、胞二磷胆碱干预组、生理盐水干预组、假手术组和正常对照组5组。前3组均在成模后当日开始每组每只分别给予参麦注射液、胞二磷胆碱和生理盐水腹腔注射干预,1次.d-1,连续14 d。其余两组不做处理。应用Y-型电迷宫对各组第60及90日龄实验大鼠测试学习能力,并于24 h后(第61、91日龄)复测,检测各实验大鼠24 h记忆保持能力。结果:经过参麦注射液和胞二磷胆碱分别干预后,其学习能力及24 h记忆能力与生理盐水干预组比较有明显改善(P<0.05),参麦注射液组与胞二磷胆碱组之间也有统计学差异(P<0.05)。结论:参麦注射液和胞二磷胆碱均可改善大鼠HIBD后的学习和记忆能力,前者优于后者。
Objective To investigate the effect of Shenmai injection on learning and remembering ability of neonatal rats with hypoxic-ischemic brain damage （HIBD）. Methods Seven,day old Sprague-Dawley（SD） rats were divided into five groups： Shenmai injection group, citicoline （ CDPC ） group, 0.9% sodium chloride （ HIBD-3 ） group, the sham group, and control group. In the first three groups, the animals were intraperitoneally injected with Shenmai injection, CDPC, HIBD-3 respectively each day for 14 days after the HIBD modeles were completed. Y-maze was used to explore the animals＇ behaviors of discrimination learning at 60 d and 90 d in all five groups. After 24 h, the same method was used to explore the animals＇ remembrance. Results Compared with HIBD-3 group, the animals＇ behaviors of discrimination learning and memory after 24 h were significantly different in Shenmai group and CDPC group （ P 〈 0.05 ） ; There was also statisticaly different between Shenmai group and CDPC group （ P 〈 0.05 ）. Conclusion Both the CDPC and Shenmai injection can improve the learning and remembering ability of rat with HIBD,the later is better than the former.
出处
《东南大学学报（医学版）》
CAS
2007年第2期90-94,共5页
Journal of Southeast University(Medical Science Edition)
基金
江苏省科委社会发展基金资助项目(BS98058)
关键词
参麦注射液
新生大鼠
缺氧缺血性脑损伤
学习
记忆
Shenmai injection
neonatal rats
hypoxic-ischemic brain damage
learning
remembrance
