摘要
目的:应用三维打印技术制备豆腐果苷零级控释片。方法:通过对片剂局部组成及结构进行选择与设计,利用三维打印技术制备了豆腐果苷馅饼型多层控释片,并对所制备的片剂进行常规分析、结构分析及体外释药试验。结果:控释片的各项性能符合相关标准;ESEM显示药片不同部分的结构与组成有差异;体外溶出实验表明三维打印技术制备的控释片中95.29的豆腐果苷在7个小时内能以零级速率释放。结论:三维打印技术能应用于豆腐果苷片研究开发中。
AIM： To use three dimensional printing （3DP） technology to prepare zero-order controlled-release tablets of helicid. METHODS： With selection of compositions and design of structure, donut-shape multi-layer tablets fabricated by 3DP were evaluated through the routine tablet analysis, structure analysis and dissolution tests in vitro. RESULTS： All the tested parameters of tablets met the relevant standards. It was clear from the ESEM imagines that different regions of the tablets had different compositions and structure. 95.29% helicid could be released at a zero-order rate in 7 h. CONCLUSION ： 3 DP can be employed in the research and development of dosage forms for helicid.
出处
《中成药》
CAS
CSCD
北大核心
2007年第3期355-359,共5页
Chinese Traditional Patent Medicine
关键词
三维打印
豆腐果苷
零级控释
馅饼型多层片
three dimensional printing
helicid
zero-order controlled-release
donut-shape multi-layer tablets
