摘要
在兔股骨粉碎性骨折创伤模型上观察了川芎嗪的保护效应。发现动物创伤后，血压呈进行性降低趋势，逐渐陷入休克低血压状态。并出现血浆乳酸脱氢酶（ＬＤＨ）及组织蛋白酶Ｄ（ＣＤ）活性增高的组织损伤表现和肺水肿、胃粘膜缺损等器官损伤表现，与此同时血浆和组织脂质过氧化产物丙二醛（ＭＤＡ）含量及组织细胞内钙含量均增高。而应用川芎嗪进行防治，则上述损伤变化明显减轻。防止了创伤性休克的发生和发展。提示：川芎嗪具有抗创伤效应。
In order to investigate the mechanism of traumatic shock and effect of ligustrazine, a medel of rabbit traumatic shock was preduced. It was found that after trauma the animal blood presure continually decreased and shock developed. While shock developing, the malondialdehyde (MDA)content, the metabolite of lipid peroxides, and the cathepsin-D significantly increased in plasma. In the tissue, the MDA and calcium content significantly increased too. At the same time, gastric ulcer and the pulmonary edema occurred. However, treatment with ligustrazine in traumatic rabbits could alleviate the changes as mentioned above and avoid shock. It was suggested that ligustrazine can protect rabbit against trauma.
出处
《中国中西医结合外科杂志》
CAS
1996年第4期255-258,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
煤炭部科学基金
