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脉动流预适应增强组织工程心脏瓣叶上内皮细胞的黏附性 被引量：1

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摘要 将受体的细胞种植于可降解材料或去细胞的异种或同种瓣膜上制成的组织工程心脏瓣膜无需抗凝，耐久性好，且有生长潜力，理论上是理想的心脏瓣膜替代物。但生理情况下，心脏瓣膜要受到高速、高压的血流冲击，简单的将内皮细胞种到瓣膜支架，经过血流冲击，细胞很快被冲掉。
作者 王克学 张镜芳 简旭华
机构地区 广东省心血管病研究所心脏外科
出处 《中华胸心血管外科杂志》 CSCD 北大核心 2007年第1期45-46,共2页 Chinese Journal of Thoracic and Cardiovascular Surgery
基金 本课题受广东省自然科学基金重点项目资助,基金编号C-010177
关键词 组织工程心脏瓣膜 内皮细胞 心脏瓣叶 黏附性 预适应 脉动流 可降解材料 同种瓣膜
分类号 R686 [医药卫生—骨科学]
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二级参考文献17

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共引文献10

同被引文献37

  • 1董念国,叶晓峰,史嘉玮,宋强,孙宗全.组织工程瓣膜天然支架去细胞方法的比较[J].中华实验外科杂志,2005,22(3):377-377. 被引量：46
  • 2Kim WG,Park JK,Lee WY.Tissue-engineered heart valve leaflets:an effective method of obtaining acellularized valve xenografts[J].Int J Artif Organs,2002,25(8):791-797.
  • 3Leyh RG,Wilhelmi M,Walles T,et al.Acellularized porcine heart valve scaffolds for heart valve tissue engineering and the risk of cross-species transmission of porcine endogenous retrovirus[J].Thorac Cardiovssc Surg,2003,126(4):1000-1004.
  • 4Jockenhoevel S,Zund G,Hoerstrup SP,et al.Fibrin gel-advantages of a new scaffold in cardiovascular tissue engineering[J].Eur J Cardiothorac Surg,2001,19(4):424-430.
  • 5Sodian R,Hoerstrup SP,Sperling JS,et al.Tissue engineering of heart valves:in vitro experiences[J].Ann Thorac Surg,2000,70(1):140-144.
  • 6Hildebrand DK,Wu ZJ,Mayer JE,et al.Design and hydrodynamic evaluation of a novel pulsatile bioreactor for biologically active heart valves[J].Ann Biomed Eng,2004,32(8):1039-1049.
  • 7Hoerstrup SP,Sodian R,Daebritz S,et al.Functional living trileaflet heart valves grown in vitrc[J].Circulation,2000,102(19 suppl 3):Ⅲ44-Ⅲ49.
  • 8Sodian R,Hoerstrup SP,Sperling JS,et al.Tissue engineering of heart valves:in vitro experiences[J].Ann Thorac Surg,2000,70 (1):140-144.
  • 9Dohmen PM,Ozaki S,Yperman J,et al.Lack of calcification of tissue engineered heart valves in juvenile sheep[J].Semin Thorac Cardiovasc Surg,2001,13(4 suppl 1):93-98.
  • 10Simon P,Kasimir MT,Seebacher G,et al.Early failure of the tissue engineered porcine heart valve SY N ERGRAFT in pediatric patients[J].Eur J Cardiothorac Surg,2003,23(6):1002-1006.

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中华胸心血管外科杂志
2007年 第1期

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