摘要
目的:观察归元口服液对环磷酰胺(CTX),顺铂(DDP)及60Co-γ治疗小鼠移植性肿瘤的增效和减毒作用.方法:以归元口服液和CTX,DDP及60Co-γ合用治疗小鼠移植性肿瘤观察其增效减毒作用.结果:归元口服液10,4和1.6g生药/kg与CTX5mg/kg合用肿瘤抑制率高于单用CTX组;归元口服液10,4g生药/kg与60Co-γ放疗合用,肿瘤抑制率分别为66.5%和47.6%,高于单用60Co-γ放疗的23.6%;归元口服液10g生药/kg与DDP1mg/kg合用,艾氏腹水癌(EAC)小鼠生存时间从(14.6±2.5)d延长到(24.2±6.9)d,生命延长率从30.1%提高到65.3%;归元口服液与CTX合用于L1210白血病小鼠,未见明显抗癌增效作用;归元口服液3个剂量均能减轻CTX对S180荷瘤小鼠化疗的毒副作用,可明显提高骨髓有核细胞数;归元口服液3个剂量均能提高60Co-γ放疗小鼠的的骨髓有核细胞数和血白细胞数.结论:归元口服液和CTX,DDP及60Co-γ合用,可提高CTX,DDP及60Co-γ的抗肿瘤作用;能减轻CTX和60Co-γ的毒副反应.
AIM： To investigate the efficacy enhancement and toxicity attenuation of Guiyuan oral solution in antitumor therapies. METHODS： The mice bearing transplanted tumors were treated by Guiyuan oral solution associated with chemotherapy or radiotherapy to study the effect of the oral solution by comparing the tumor weight, survival time, white blood cells, and nucleated cells in bone marrow between association therapy groups and simple chemotherapy or radiotherapy groups. RESULTS： The tumor weights of mice bearing sarcoma180 were obviously decreased in the groups of cyclophosphamide （ CTX 5 mg/kg） associated with Guiyuan oral solution（ 10, 4, 1.6 g/kg） as compared with that in the CTX group. When both 60^Co-γ and Guiyuan oral solution（ 10, 4 g/kg） were administered to mice with sarcorea180, the tumor weights were decreased significantly, and tumor inhibition rates were 66. 5% and 47.6 %, respectively, significantly higher than that in.simple 60^Co-γ group （23.6 % ）. When both cisplatin （ DDP, 1 mg/kg） and Guiyuan oral solution （ 10 g/ kg） were administered to mice with Ehrlich＇ s ascites carcinoma, the survival time of the mice was prolonged significantly [ （ 14.6 ± 2.5 ） d vs （24.2 ±6.9） d ], the rate of the prolonged survival time was raised from 30. 1% to 65. 3%. When Guiyuan oral solution （10, 4, 1.6 g/kg） associated with CTX （5 mg/kg） was administered to mice with leukemia L1210, the effect of anticancer was no obviously increased. Guiyuan oral solution （10, 4,1.6 g/kg） could increase the number of nucleated cells in medulla of mice treated by CTX and 60^Co-γ and the number of white blood cells in blood of mice treated by CTX. CONCLUSION： Guiyuan oral solution can increase the efficacy and decrease the toxicity of chemotherapy or radiotherapy for transplanted tumors in mice.
出处
《第四军医大学学报》
CAS
北大核心
2007年第6期496-499,共4页
Journal of the Fourth Military Medical University
关键词
归元口服液
肿瘤
增效
减毒
Guiyuan oral solution
neoplasms
efficacy enhancement
toxicity attenuation
