摘要
基质金属蛋白酶-9(MMP-9)能降解和重塑造细胞外基质,破坏血—脑屏障,导致脑损伤和脑水肿。了解MMP-9在脑缺血再灌注损伤中的作用、表达、影响其表达的因素及有关抗体的研究及应用,可以为脑梗死的早期诊断、预防和治疗开辟新的途径。
Matrix metalloproteinases-9 （MMP-9） can degrade and remode extracelluar matrix, destruct the blood-brain barrier. These led to the cerebral injury and brain edema. Understanding of the expression and role of MMP-9, the factor affecting its expression and the application of MMP-9 antibody during cerebral ischemic/repeffusion injury is important. It can find new appraches in the early diagnosis, prevention, and treatment.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第5期565-568,共4页
China Journal of Modern Medicine
关键词
基质金属蛋白酶-9
脑缺血
matrix metalloproteinases-9
cerebral ischemia
