摘要
目的:检测中药牛至单体百里香酚、香荆芥酚、迷迭香酸和咖啡酸体外抗阴道毛滴虫的作用,以寻找不良反应少、疗效较高的药物。方法:观察牛至单体在不同时间和不同浓度对培养的阴道毛滴虫虫体形态的变化、存活率(%)和最低有效浓度。结果:百里香酚和香荆芥酚在5mmol/L杀灭阴道毛滴虫效应比甲硝唑快1倍;而百里香酚和香荆芥酚最低有效浓度分别为1.25、2.5mmol/L,比甲硝唑分别弱1和2倍。迷迭香酸和咖啡酸抗滴虫效应比较弱。结论:百里香酚和香荆芥酚具有较强杀灭阴道毛滴虫作用。
AIM： To study the effect of four monomers （thymol, cavacrol, rosmarinic acid and caffeic acid） extracted from oregano against Trichomonas vaginalis. MERHODS： The morphologie change, survival rate and MEC of the monomers on Trichomonas vaginalis were observed in different times and at different concentrations in vitro. RESULTS： The initial effect of Thymol and Cavacrol （5 mmol/L） against Triehomonas vaginalis was one time quicker than metronidazole. The MEC of thymol and eavacrol was 1.25, 2.5 mmol/L respectively at 24 h,which was respectively one and two times weaker than metronidazole. The effect of rosmarinic acid and caffeic acid on Trichomonas vaginalis was weak. CONCLU- SIONS： Thymol and cavacrol have stronger effect against Trichomonas vaginalis.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2007年第2期182-186,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
湖南省卫生厅基金资助项目(204062)
湖南省教育厅重点基金资助项目(03A040)
国家教育部重点基金资助项目(204095)
国家"十五"攻关项目(02EFN214300457)
关键词
百里香酚
香荆芥酚
迷迭香酸
咖啡酸
甲硝唑
阴道毛滴虫
最低有效浓度
thymol
cavacrol
rosmarinic acid
caffeic acid
metronidazole
Trichomonas vaginalis
minimal effective concentration
