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血管内皮生长因子在乳腺浸润性导管癌中的表达及意义 被引量:5

Significance and expression of vascular endothelial growth factor in invasive ductal carcinoma of breast.
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摘要 目的 检测乳腺浸润性导管癌中血管内皮生长因子(VEGF)的表达水平及肿瘤微血管密度(MVD)值,探讨VEGF、MVD水平及与临床病理学特征之间的相关性。方法 采用免疫组化染色法(SP法)分别检测88例乳腺癌患者术后标本中VEGF的表达水平、MVD值以及C-erbB-2表达情况。结果 88例标本中VEGF阳性62例,阳性率为70.45%;淋巴结转移组中VEGF表达水平高于未转移组(P〈0.05);相对中晚期组(Ⅱb-Ⅲ)中VEGF表达水平高于相对早期组(Ⅰ-Ⅱa)(P〈0.05);C-erbB-2阳性组中VEGF表达水平高于阴性组(P〈0.05);随着癌组织学分级的升高,VEGF表达水平也有逐渐升高趋势(P〈0,05)。随着癌组织学分级的升高,MVD值也呈现出逐渐增高趋势(P〈0.01);MVD值随着VEGF表达水平增高而增高(P〈0.01)。结论 VEGF在乳腺浸润性导管癌的肿瘤血管生成及转移过程中可能发挥重要的调控作用。VEGF和MVD值可作为反映乳腺癌生物学行为的指标之一。以VEGF为靶点的抗血管生成治疗策略有望成为治疗C-erbB-2阳性患者的一条新的途径。 Objective To detect the expression of vascular endothelial growth factor(VEGF) and microvessel density count in invasive ductal Carcinoma of breast to clarify the association of VEGF expression and MVD count with the clinicopathologic features. Methods The expressions of VEGF, C-erbB-2 and MVD count in 88 cases of invasive ductal carcinoma of breast were examined by immunohistochemistry staining (SP-method). Results Sixtytwo out of the eighty-eight specimens of breast carcinoma showed positive expression of VEGF( 70.45% ). The positive rate of VEGF in cases with lymph node metastasis was higher than that without lymph node metastasis (P 〈 0.05 ). The positive rate of VEGF in stage Ⅱb-Ⅲ was higher than that in stage Ⅰ-Ⅱa (P 〈 0.05 ). The positive rate of VEGF in C-erbB-2 positive group was higher than that in C-erbB-2 negative group ( P 〈 0.05 ). Higher expression of VEGF was observed in cases with higher tissue differentiation degree ( P 〈 0.05 ). Also, significant higher MVD count was observed in cases with higher tissue differentiation degree ( P 〈 0.01 ). The MVD count increased significantly with the increase of the expression of VEGF ( P 〈 0.01 ). Conclusion In invasive ductal carcinoma of breast, angiogenesis and metastasis are mediated mainly by VEGF. The expression of VEGF and MVD might be reference predictors for the biological behavior of breast carcinoma. The antiangiogenic therapy which uses VEGF as a target would become a new method to treat patients who are C-erbB-2 positive in the future.
出处 《中国综合临床》 北大核心 2007年第4期338-340,共3页 Clinical Medicine of China
基金 河北省科学技术研究与发展资助项目(0527611016)
关键词 乳腺浸润性导管癌 血管内皮生长因子 微血管密度 Invasive ductal carcinoma of breast Vascular endothelial growth factor Microvessel density
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  • 1Weidner N, Folkman J, Pozza F, et al. Tumor anglogenesis: a new significant and independent prognostic indicator in early-stage breast,careinoma[J].J Natl Cancer Inst, 1992,84(24) : 1875-1887.
  • 2Folkman J. What is the evidence that tumors are angiogenesis dependent[J] ? J Natl Cancer Inst, 1990,82( 1 ) :4-6.
  • 3Tsutsui S, Kume M, Era S, et al. Prognostic value of microvossel density in invasive ductal carcinoma of the breast[J].Breast Cancer, 2003,10(4) :312-319.
  • 4陈映波,万德森,詹友庆,周志伟,李威,陈功.直肠癌微血管密度与转移、复发的关系[J].癌症,2004,23(10):1203-1206. 被引量:6
  • 5朱志华,戎铁华,曾灿光,吴秋良,马芸,黄晓平,李宝江,张蓬原,赵进明,胡祎,张仕义,余辉,马国伟,张兰军,温浙盛,傅剑华,龙浩.Ⅰ~Ⅱ期非小细胞肺癌组织中VEGF的表达和微血管密度与预后的关系[J].癌症,2005,24(7):865-869. 被引量:10
  • 6Chhieng DC, Tabbara SO, Marley EF, et al. Micrevessel density and vascular endothelial growth factor expression in infiltrating lobular mammary carcinoma[J].Breast J,2003,9 ( 3 ) : 200-207.
  • 7Martin L,Green B, Renshaw C, et al. Examining the technique of angiogenesis assessment in invaslve breast cancer[J]. Br J Cancer,1997,76(8) : 1046-1054.
  • 8Elagoz S, Egilmez R, Koyuncu A, et al. The intratumoral micrvessel density and expression of bFGF and nm23-H1 in colorectal cancer[ J ]. Pathol Oncol Res,2006,12 ( 1 ) :21-27.
  • 9Ahmed SI, Thomas AL, Steward WP, et al. Vaseular endothelial growth factor (VEGF) inhibition by small molecules [ J ]. J Chemother,2004,16( Suppl 4) :59-63.
  • 10Tammela T, Enholm B, Alitalo K, et al. The biology of vascular endothelial growth factors [ J ]. Cardiovasc Res, 2005,65 ( 3 ) : 550-563.

二级参考文献62

  • 1Weidner N, Semple JP, Welch WR, et al. Tumor angiogenesis and metastasis: correlation in invasive breast carcinoma [J]. N Engl J Med, 1991, 324:1-8.
  • 2Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma [J]. J Natl Cancer Inst, 1992, 84(24): 1875-1887.
  • 3Bossi P, Viale G, Lee AK, et al. Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlation [J]. Cancer Res, 1995, 55(21):5049-5053.
  • 4Nakasaki T, Wada H, Shigemori C, et al. Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer [J]. Am J Hematol, 2002, 69(4): 247-254.
  • 5Barozzi C, Ravaioli M, D' Errico A, et al. Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel [J]. Cancer, 2002, 94 (3): 647-657.
  • 6Engel CJ, Bennett ST, Chambers AF, et al. Tumor angiogenesis predicts recurrence in invasive colorectal cancer when controlled for Dukes staging [J]. Am J Surg Pathol, 1996, 20(10): 1260-1265.
  • 7Saeki T, Tanada M, Takashima S, et al. Correlation between expression of platelet-derived endothelial cell growth factor (thynidine phosphorylase) and microvessel density in early-stage human colon carcinomas [J]. J Clin Oncol, 1997, 27(4): 227-230.
  • 8Takebayashi Y, Aklyamta S, Yamada K, et al. Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma [J].Cancer, 1996, 78 (2): 226-231.
  • 9Lindmark G, Gerdin B, Sundberg C, et al. Prognostic significance of the microvascular count in colorectal cancer [J]. J Clin Oncol, 1996, 14(2): 461-466.
  • 10Tanigawa N, Amaya H, Matsumura M, et al. Tmnor angiogenesis and mode of metastasis in patients with colorectal cancer [J] .Cancer Res, 1997, 57(6): 1043-1046.

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