摘要
目的:探讨更昔洛韦治疗婴儿巨细胞病毒性肝炎的不良反应。方法:更昔洛韦诱导治疗65例婴儿巨细胞病毒性肝炎,治疗前后复查血常规、肝肾功能、心肌酶谱,将结果进行配对样本t检验,观察对血常规、肝肾功能、心肌酶谱有无影响,并观察治疗过程中的不良反应。结果:更昔洛韦致使婴幼儿的WBC、PLT下降,经比较差异有统计学意义(P<0.01),部分患儿ALT升高,少数患儿出现皮疹、静脉炎。结论:更昔洛韦会抑制WBC、PLT,并有致ALT升高的可能,但这些影响可用其他药物缓解,在用药前应向家长说明。
Objective：To estimate the adverse drug reactions of ganciclovir in treating cytomegalovirus hepatitis. Methods： 65 cases of cytomegalovirus hepatitis were treated with ganciclovir. Changes of blood, liver and kidney function, myocardial enzymes and other uncomfortable reactions were observed before and after the treatment, and then the results were statistically analyzed. Results： Ganciclovir could reduce WBC, PLT, and the differences were significant （ P 〈 0.01 ）. And the raise of ALT was observed in some cases and phlebitis and skin rash in a few. Conclusions： Ganciclovir can induce the inhibition of WBC, PLT and the raise of ALT, but these results can be relieved by other drugs, so the doctor should explain these reactions to relatives of patients.
出处
《儿科药学杂志》
CAS
2007年第2期20-22,共3页
Journal of Pediatric Pharmacy
关键词
更昔洛韦
婴儿
巨细胞病毒
肝炎
不良反应
Ganciclovir
Infants
Cytomegaloviral
Hepatitis
Adverse drug reactions
