摘要
目的:探讨不同浓度新型促渗剂壬代环戊双醚对丹参凝胶的透皮吸收影响。方法:采用改良Frans扩散池进行体外透皮吸收实验,高效液相色谱法检测丹参酮ⅡA。结果:壬代环戊双醚含量在4.0%时透皮吸收最好。结论:壬代环戊双醚具有较好的促渗作用,是较好的新型促渗剂。
Objective： To choose the most suitable concentration of 2-n-nonyl-1,3-dioxolane as a penetration enhancer in tanshinone gel preparation. Method： In vitro, transdermal absorption was studied using improved Frans equipment and rats skin. Tanshinone ⅡA was tested by HPLC. Result： The 4.0% concentration of 2-n-nonyl-1, 3-dioxolane enhanced the transdermal absorption significantly in the preparation. Conclusion： 2-n-nonyl-1, 3-dioxolane was a new effective permeaton enhancer.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第6期487-489,共3页
China Journal of Chinese Materia Medica
基金
福建省教育厅课题(JA04216)
关键词
壬代环戊双醚
丹参酮ⅡA
渗透促进剂
新辅料
2-n-nonyl-1,3-dioxolane
tanshinoneⅡA
permeaton enhancer
new excipients
