摘要
应用免疫组化法研究４２例胰腺癌组织中雌激素受体（ＥＲ）、孕酮受体（ＰＲ）和表皮生长因子受体（ＥＧＦＲ）表达及相互关系。ＥＲ、ＰＲ、ＥＧＦＲ阳性率分别为６６．７％、５０％和４５．２％；高分化腺癌和组织学分级Ⅰ级病例ＥＲ、ＰＲ阳性率高于低分化腺癌和组织学分级Ⅲ级病例，ＥＧＦＲ则相反；ＥＧＦＲ阳性病例易发生转移；ＥＲ、ＰＲ表达与ＥＧＦＲ表达存在密切负相关。结果提示：ＥＲ、ＰＲ阳性胰腺癌预后较好，而ＥＧＦＲ阳性胰腺癌预后较差；检测ＥＲ和／或ＰＲ同时检测ＥＧＦＲ可更准确预测胰腺癌激素依赖性和提高内分泌治疗的有效率。
The expression and biological
significance of ER(estrogen receptor),PR(progesterone receptor),and EGFR(epidermal growth
factor receptor)in 42 cases ofpancreatic carcinoma were studied by immunohistochemical
method. The positive ratesof ER,PR,EGFR were 66.7%, 50% and 45.2%,respectively,The
positive rates of ERand PR in well-differentiated gradeⅠadenocarcinoma were significantly
higher thanthat of poorly-differentiated grade Ⅲ adenocarcinoma.That of EGFR in
well-differenti-ated and grade Ⅰ adenocarcinoma was significantly lower than that of
poorly-differ-entiated grade Ⅲ adenocarcinoma.There were negative correlation between
theexpressions of ER,PR and EGFR.These results suggested that cases with positive ERand
PR might have a better prognosis,while those with positive EGFR might have aworse
prognosis.Assays of ER and /or PR or together with EGFR might be helpful inthe prediction of
sex hormone dependence and effect of endocrine therapy inpancreatic carcinoma.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1996年第2期94-96,T000,共4页
Chinese Journal of Digestion
关键词
胰腺肿瘤
雌激素
孕酮
表皮生长因子
受体
Pancreatic neoplasm Estrogen receptor Progesterone receptorEpidermal growth factor receptor
