摘要
目的制备复方黄芩巴布剂并进行透皮释放度的测定。方法正交设计法对巴布剂基质配比进行的实验研究;应用自制的透皮释放扩散池装置进行透皮释放度研究,高效液相色谱法测定释放液中黄芩苷的含量。结果复方黄芩巴布剂基质以阿拉伯胶∶西黄蓍胶∶压敏胶∶甘油∶氧化锌=2∶1∶1∶0.1∶0.3为最适宜;24 h的透皮释放量为(450±30)ng/cm2。结论该制备工艺简单,制成的巴布剂黏性适中、质量可控、释药稳定。
Objective To prepare the complex scutellariae baicalensis cataplasm and to determine transdermal release. Methods The orthogonal design wad used to optimize the matrix formulation. The transdermal release was determined by a self-designed diffusion cell system,and the content of baicalin was detected by HPLC. Results The matrix formulation of the complex scutellariae baicalensis eataplasm was made with gum acacia： gum tragaeabth： gum stamp sensitive： glycerine： zinc oxide = 2 ： 1 ： 1 ： 0.1 ： 0.3. The 24 h accumulative release was （450 ＋ 30） ng/cm^2. Conclusion The preparation of complex scutellariae baiealensis eataplasm is simple, the stickness is suitable, and the transdermal release is stability.
出处
《山西医科大学学报》
CAS
2007年第3期231-233,共3页
Journal of Shanxi Medical University
关键词
色谱法
高压液相
复方黄芩巴布剂
正交设计
透皮释放度
chromatography, high pressure liquid
scutellaria baicalensis eataplasm
orthogonal design
transdermal release
