摘要
目的 了解山西省继发性肾小球肾炎（SGN）的临床表现，病理类型和流行病学特点。方法 回顾性分析我院1993—07--2006—10收治的265例因继发性肾小球肾炎而行肾活检者的性别、年龄、病理类型及临床表现。结果 ①本组265例肾脏疾病患者行肾活检时的平均年龄30．8±13．1岁（范围8—74）岁，男女比为0．9：1。②继发性肾小球肾炎中，最常见的是紫癜性肾炎（38．9％），其次狼疮性肾炎（27．2％）、乙肝病毒相关性肾炎（10．9％）。③本组常见的临床表现依次是肾病综合征（47．5％），肾炎综合征（30．6％）、慢性肾衰竭（11．3％）、无症状尿检异常（4．5％）、急性肾衰竭（4．2％）及急进性肾小球肾炎（1．9％）。④表现为肾病综合征的常见病理类型依次是狼疮性肾炎（33．3％）、紫癜性肾炎（30．9％）、乙型肝炎病毒相关性肾炎（15．1％）。表现为慢性肾衰竭的常见病理类型依次是高血压肾损害（33．3％）、紫癜性肾炎（23．3％）、狼疮性肾炎（16．7％）。表现为急性肾衰竭的病理类型则以狼疮性肾炎（54．5％）及紫癜性肾炎（27．3％）为主。结论 继发性肾小球肾炎以女性多见，成人及儿童继发性肾小球肾炎中紫癜性肾炎是首要病因。肾病综合征是最常见的临床表现，其最常见的病理类型是狼疮性肾炎；慢性肾衰竭最常见的病理类型是高血压肾损害；急性肾衰竭最常见的病理类型是狼疮性肾炎。
Objective To survey the clinical features, pathological types and epidemiologic characteristics of a major groups of secondary glomerulonephritis（SGN） in Shanxi province. Methods The data of 265 patients with secondary glomerulonephritis including sex, age, pathological type, clinical features were reviewed retrospectively, and all patients had been examined by renal biopsy in our hospital from July 1993 to October 2006. Results （1）The mean age was 30.8 ± 13.1 years （8 - 74 years） in 265 patients with secondary glomerulonephritis with a male to female ratio of 0.9：1. （2）The most frequent cause of SGN was Henoch-Sclonlein purpura glomerulonephritis, and followed by lupus nephritis （LN） and hepatitis B virus associated glomerulonephritis. （3）The clinical manifestationsof 265 cases were nephrotic syndrome （NS） （47.5%）, nephritic syndrome （30.6%）, chronic renal failure （CRF） （11.3 % ）, asymptomatic urinary abnormalities （ALIA） （4.5 % ）, acute renal failure（ARF） （4.2 % ）, rapidly progressive glomerulonephritis（RPGN） （1.9%）. （4）LN, Henoch-Sclonlein purpura glomerulonephritis and hepatitis B virus associated glomerulonephritis were the most frequent diagnoses in patients with nephrotic syndrome. While hypertensive nephroselerosis, Henoch-Sclonlein purpura glomerulonephritis, lupus nephritis were frequently featured as CRF. LN and Henoch-Sclonlein purpura were frequendy found in patients with ARF. Conclusion Female is predominant in SGN. The main cause of SGN is Henoch-Sclonlein purpura glomerulonephritis both in adults and children. The most frequent clinical syndrome is NS. The most frequent pathological types of NS,CRF, ARF are LN, hypertensive nephrosclerosis, LN, respectively.
出处
《山西医科大学学报》
CAS
2007年第3期243-246,263,共5页
Journal of Shanxi Medical University
