摘要
目的:探讨急性等容血液稀释(ANH)对兔血液流变学和微循环的影响。方法:16只雄性健康家兔随机分为对照组(A组)和血液稀释组(B组)。两组均常规输注乳酸林格氏液0.5ml.kg-1.min-1补充生理需要量。B组在麻醉诱导完成后30min内放血,同时等速、等量输注琥珀酰明胶,使Hct下降至30%左右。监测两组麻醉诱导后即刻(T0)、60min(T1)、90min(T2)的血液流变学及耳廓微循环血流量和肠系膜微动脉管径、微循环血流速度、血管数、功能血管数的变化。结果:B组血液稀释后于T1、T2血浆及全血粘度下降(P<0.05或P<0.01),微循环的血流量和血流速度增加(P<0.01),微动脉管径增大(P<0.05),功能血管数增加(P<0.05)。A组同期的血液流变学和微循环变化不大。结论:急性等容血液稀释可改善机体的血液流变性和微循环。
Objective：To observe the influence of acute normonistic hemodilution（ANH） on hemorrheology and relation. Methods： Sixteen male rabbits were divided randomly into two groups： control group （group A,n=8） and ANH group（group B,n=8）. Both groups received Ringer lactate solution 0. 5 ml·kg^-1·min^-1 to supply the physiological requirement. In group B, ANH was accomplished in 30 minutes by exchanging blood with an equal volume of Gelofusine after induction of anesthesia, in order to reduce the hematocrit（Hct） to about 30%. Blood samples of both groups were collected at the moment（T0） .60 min（T1） and 90 min（T2 ） after induction of anesthesia for the measurement of the parameters of hemorrheology. The relation of auricle and mesentery was also monitored.Results： In group B, blood plasma viscosity and whole blood viscosity decreased at T1 and T2 （P〈0. 05 or 0. 01 ）, the volume and velocity of blood stream of microcirculation increased（P〈0. 01 ）, the diameter of microartery and the number of functional capillary increased （P〈0. 05） after ANH. Those parameters of hemorrheology and relation changed little at the same time in group A. Conclusion：ANH can improve hemorrheology and microcirculation.
出处
《西南国防医药》
CAS
2007年第2期170-172,共3页
Medical Journal of National Defending Forces in Southwest China
