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“链接”化学及其在药物研究中的应用 被引量：2

Click chemistry and its applications in drug research
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摘要 介绍了“链接”化学(Click Chemistry)的产生背景、基本概念、反应特点及类型,综述了近年来“链接”化学作为一种新型的组合合成方法在合成先导化合物库、标记蛋白质及DNA等方面的应用,并对“链接”化学的发展前景作了展望。 In this review, the background and basic concepts of click chemistry are introduced, and also the specific features of click chemistry and some classic examples of click chemistry are presented. As a new type of synthetic method, click chemistry has been used in synthesizing lead discovery libraries, profiling protein in vivo and labeling DNA and so on. At last, the possible future of click chemistry is reviewed.
作者 胡君 李映 凌云 杨新玲
机构地区 中国农业大学应用化学系
出处 《化学试剂》 CAS CSCD 北大核心 2007年第4期207-211,228,共6页 Chemical Reagents
基金 国家重点基础研究发展计划(973计划)资助项目(2003CB114400)
关键词 “链接”化学 药物研究 合成 click chemistry drug research synthesis
分类号 O621.12 [理学—有机化学]
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参考文献26

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共引文献14

同被引文献27

  • 1陈功,殷珺.磁性纳米材料在生物医学领域的应用[J].中国医学装备,2006,3(8):30-32. 被引量：11
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化学试剂
2007年 第4期

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